8G5E

Crystal Structure of SETDB1 Tudor domain in complex with UNC6535

This is a non-PDB format compatible entry.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Histone-lysine N-methyltransferase SETDB1	polymer	225	26337.3	1	UniProt (Q15047) Pfam (PF18300) Pfam (PF18359) Pfam (PF18358) In PDB	Homo sapiens (human)	ERG-associated protein with SET domain,ESET,Histone H3-K9 methyltransferase 4,H3-K9-HMTase 4,Lysine N-methyltransferase 1E,SET domain bifurcated 1
2	A	N~4~-[6-(dimethylamino)hexyl]-N~2~-[5-(dimethylamino)pentyl]-6,7-dimethoxyquinazoline-2,4-diamine	non-polymer		460.7	1	Chemie (YOH)
3	A	UNKNOWN ATOM OR ION	non-polymer			7	Chemie (UNX)
4		water	water		18.0	100	Chemie (HOH)

Sequence modifications

A: 196 - 403 (UniProt: Q15047)

PDB	External Database	Details
Met 179	-	initiating methionine
His 180	-	expression tag
His 181	-	expression tag
His 182	-	expression tag
His 183	-	expression tag
His 184	-	expression tag
His 185	-	expression tag
Ser 186	-	expression tag
Ser 187	-	expression tag
Gly 188	-	expression tag
Arg 189	-	expression tag
Glu 190	-	expression tag
Asn 191	-	expression tag
Leu 192	-	expression tag
Tyr 193	-	expression tag
Phe 194	-	expression tag
Gln 195	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	26337.3
Non-Polymers*	Number of molecules	8
	Total formula weight	460.7
All*	Total formula weight	26798.0

*Water molecules are not included.