8G2H

Crystal Structure of PRMT4 with Compound YD1113

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Histone-arginine methyltransferase CARM1	polymer	359	40946.5	1	UniProt (Q86X55) Pfam (PF06325) Pfam (PF22528)	Homo sapiens (human)	Coactivator-associated arginine methyltransferase 1,Protein arginine N-methyltransferase 4
2	B (A)	5'-S-[2-(benzylcarbamamido)ethyl]-5'-thioadenosine	non-polymer		459.5	1	Chemie (YVU)
3	C, D (A)	GLYCEROL	non-polymer		92.1	2	Chemie (GOL)
4	E (A)	SODIUM ION	non-polymer		23.0	1	Chemie (NA)
5	F, G, H, I, J (A)	UNKNOWN ATOM OR ION	non-polymer			5	Chemie (UNX)
6	K (A)	water	water		18.0	185	Chemie (HOH)

Sequence modifications

A: 140 - 480 (UniProt: Q86X55)

PDB	External Database	Details
Met 122	-	initiating methionine
His 123	-	expression tag
His 124	-	expression tag
His 125	-	expression tag
His 126	-	expression tag
His 127	-	expression tag
His 128	-	expression tag
Ser 129	-	expression tag
Ser 130	-	expression tag
Gly 131	-	expression tag
Arg 132	-	expression tag
Glu 133	-	expression tag
Asn 134	-	expression tag
Leu 135	-	expression tag
Tyr 136	-	expression tag
Phe 137	-	expression tag
Gln 138	-	expression tag
Gly 139	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	40946.5
Non-Polymers*	Number of molecules	9
	Total formula weight	666.7
All*	Total formula weight	41613.2

*Water molecules are not included.