8FZ3

Sterile Alpha Motif of Human Translocation ETS Leukemia, Non-Polymer Crystal Form

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D (A, B, C, D)	Transcription factor ETV6, Activated CDC42 kinase 1 fusion	polymer	170	19810.5	4	UniProt (P41212) UniProt (Q07912) Pfam (PF02198)	Homo sapiens (human)	ETS translocation variant 6,ETS-related protein Tel1,Tel,ACK-1,Tyrosine kinase non-receptor protein 2
2	E, G (A, C)	CHLORIDE ION	non-polymer		35.5	2	Chemie (CL)
3	F (B)	PHOSPHATE ION	non-polymer		95.0	1	Chemie (PO4)
4	H, I, J, K (A, B, C, D)	water	water		18.0	31	Chemie (HOH)

Sequence modifications

A, B, C, D: 12 - 88 (UniProt: P41212)

PDB	External Database	Details
Gly 1	-	expression tag
His 2	-	expression tag
His 3	-	expression tag
His 4	-	expression tag
His 5	-	expression tag
His 6	-	expression tag
His 7	-	expression tag
His 8	-	expression tag
His 9	-	expression tag
His 10	-	expression tag
His 11	-	expression tag
Ser 45	Arg 80	engineered mutation
Glu 77	Val 112	engineered mutation
Gly 89	-	linker

A, B, C, D: 90 - 170 (UniProt: Q07912)

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	79242.0
Non-Polymers*	Number of molecules	3
	Total formula weight	165.9
All*	Total formula weight	79407.9

*Water molecules are not included.