8FY2
E3:PROTAC:target ternary complex structure (VCB/WH244/BCL-2)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | von Hippel-Lindau disease tumor suppressor | polymer | 180 | 20729.5 | 1 | UniProt (P40337) Pfam (PF01847) Pfam (PF17211) | Homo sapiens (human) | Protein G7,pVHL |
| 2 | B (B) | Elongin-B | polymer | 118 | 13147.8 | 1 | UniProt (Q15370) Pfam (PF00240) | Homo sapiens (human) | EloB,Elongin 18 kDa subunit,RNA polymerase II transcription factor SIII subunit B,SIII p18,Transcription elongation factor B polypeptide 2 |
| 3 | C (C) | Elongin-C | polymer | 96 | 10843.4 | 1 | UniProt (Q15369) Pfam (PF03931) | Homo sapiens (human) | EloC, Elongin 15 kDa subunit, RNA polymerase II transcription factor SIII subunit C, SIII p15, Transcription elongation factor B polypeptide 1 |
| 4 | D (D) | Apoptosis regulator Bcl-2 | polymer | 209 | 23017.9 | 1 | UniProt (P10415) Pfam (PF02180) Pfam (PF00452) | Homo sapiens (human) | |
| 5 | E (D) | N-({4-[2-(4-{[(4R)-4'-chloro-4-methyl-6-{[4-(4-{[4-{[(2R)-4-[(1R,4R)-2-oxa-5-azabicyclo[2.2.1]heptan-5-yl]-1-(phenylsulfanyl)butan-2-yl]amino}-3-(trifluoromethanesulfonyl)benzene-1-sulfonyl]carbamoyl}phenyl)piperazin-1-yl]methyl}-2,3,4,5-tetrahydro[1,1'-biphenyl]-4-yl]methyl}piperazin-1-yl)-2-oxoethyl]piperazin-1-yl}acetyl)-3-methyl-L-valyl-(4S)-4-hydroxy-N-{(1S)-1-[4-(4-methyl-1,3-thiazol-5-yl)phenyl]ethyl}-L-prolinamide | non-polymer | 1681.5 | 1 | Chemie (YFH) |
Sequence modifications
A: 54 - 213 (UniProt: P40337)
D: 1 - 207 (UniProt: P10415)
| PDB | External Database | Details |
|---|---|---|
| Met 34 | - | expression tag |
| Gly 35 | - | expression tag |
| Ser 36 | - | expression tag |
| Ser 37 | - | expression tag |
| His 38 | - | expression tag |
| His 39 | - | expression tag |
| His 40 | - | expression tag |
| His 41 | - | expression tag |
| His 42 | - | expression tag |
| His 43 | - | expression tag |
| Ser 44 | - | expression tag |
| Ser 45 | - | expression tag |
| Gly 46 | - | expression tag |
| Leu 47 | - | expression tag |
| Val 48 | - | expression tag |
| Pro 49 | - | expression tag |
| Arg 50 | - | expression tag |
| Gly 51 | - | expression tag |
| Ser 52 | - | expression tag |
| His 53 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Gly -1 | - | expression tag |
| Ser 0 | - | expression tag |
| Val 8 | Gly 8 | conflict |
| Gly 87 | Ser 87 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 67738.6 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 1681.5 | |
| All* | Total formula weight | 69420.1 |
