8FY2
E3:PROTAC:target ternary complex structure (VCB/WH244/BCL-2)
Functional Information from GO Data
Chain | GOid | namespace | contents |
B | 0001222 | molecular_function | transcription corepressor binding |
B | 0005515 | molecular_function | protein binding |
B | 0005634 | cellular_component | nucleus |
B | 0005654 | cellular_component | nucleoplasm |
B | 0005829 | cellular_component | cytosol |
B | 0006367 | biological_process | transcription initiation at RNA polymerase II promoter |
B | 0006368 | biological_process | transcription elongation by RNA polymerase II |
B | 0016567 | biological_process | protein ubiquitination |
B | 0030891 | cellular_component | VCB complex |
B | 0031462 | cellular_component | Cul2-RING ubiquitin ligase complex |
B | 0031466 | cellular_component | Cul5-RING ubiquitin ligase complex |
B | 0031625 | molecular_function | ubiquitin protein ligase binding |
B | 0032436 | biological_process | positive regulation of proteasomal ubiquitin-dependent protein catabolic process |
B | 0065003 | biological_process | protein-containing complex assembly |
B | 0070449 | cellular_component | elongin complex |
B | 0140958 | biological_process | target-directed miRNA degradation |
Functional Information from PROSITE/UniProt
site_id | PS01080 |
Number of Residues | 19 |
Details | BH1 Apoptosis regulator, Bcl-2 family BH1 motif signature. LFrDGv.NWGRIVAFFeFGG |
Chain | Residue | Details |
D | LEU137-GLY155 |
site_id | PS01258 |
Number of Residues | 12 |
Details | BH2 Apoptosis regulator, Bcl-2 family BH2 motif signature. WIqdnGGWDaFV |
Chain | Residue | Details |
D | TRP188-VAL199 |
site_id | PS01259 |
Number of Residues | 15 |
Details | BH3 Apoptosis regulator, Bcl-2 family BH3 motif signature. VhltLRqAGDDFSRR |
Chain | Residue | Details |
D | VAL93-ARG107 |
site_id | PS01260 |
Number of Residues | 21 |
Details | BH4_1 Apoptosis regulator, Bcl-2 family BH4 motif signature. DNREIVmKYIHYKLSQRGYeW |
Chain | Residue | Details |
D | ASP10-TRP30 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 1 |
Details | MOD_RES: N-acetylmethionine => ECO:0000269|Ref.6, ECO:0007744|PubMed:19413330, ECO:0007744|PubMed:22814378 |
Chain | Residue | Details |
B | MET1 |
site_id | SWS_FT_FI2 |
Number of Residues | 1 |
Details | MOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:P62869 |
Chain | Residue | Details |
B | THR84 |
site_id | SWS_FT_FI3 |
Number of Residues | 2 |
Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P62869 |
Chain | Residue | Details |
B | SER111 | |
B | SER108 |
site_id | SWS_FT_FI4 |
Number of Residues | 1 |
Details | MOD_RES: Phosphoserine; by MAPK8 => ECO:0000269|PubMed:18570871 |
Chain | Residue | Details |
D | GLY87 |