8FXY

Cryo-EM structure of cowpox virus M2 in complex with human B7.2 (hexameric ring)

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C, E, G, I... (A, B, D, F, I...)	CPXV040 protein	polymer	204	23396.4	6	UniProt (Q8QN22) Pfam (PF04887)	Cowpox virus (Brighton Red)
2	B, D, F, H, J... (H, C, E, G, J...)	T-lymphocyte activation antigen CD86	polymer	219	25082.5	6	UniProt (P42081) Pfam (PF07686)	Homo sapiens (human)	Activation B7-2 antigen,B70,BU63,CTLA-4 counter-receptor B7.2,FUN-1
3	AA, BA, CA, DA, M... (I, K, A, B, D...)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	18	Chemie (NAG)

Sequence modifications

A, B, D, F, I, K: -3 - 197 (UniProt: Q8QN22)

PDB	External Database	Details
Lys -6	-	expression tag
Pro -5	-	expression tag
Glu -4	-	expression tag

H, C, E, G, J, L: 1 - 218 (UniProt: P42081)

PDB	External Database	Details
Met 0	-	initiating methionine
Ile 160	Val 185	variant

Contents of the asymmetric unit

Polymers	Number of chains	12
	Total formula weight	290873.2
Non-Polymers*	Number of molecules	18
	Total formula weight	3981.7
All*	Total formula weight	294854.9

*Water molecules are not included.