8FXW

Cryo-EM structure of cowpox virus M2 in complex with human B7.1 (hexameric ring)

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C, E, G, I... (A, B, D, F, I...)	CPXV040 protein	polymer	225	25809.9	6	UniProt (Q8QN22) Pfam (PF04887)	Cowpox virus (Brighton Red)
2	B, D, F, H, J... (H, C, E, G, J...)	T-lymphocyte activation antigen CD80	polymer	201	22993.1	6	UniProt (P33681) Pfam (PF07686) Pfam (PF08205)	Homo sapiens (human)	Activation B7-1 antigen,BB1,CTLA-4 counter-receptor B7.1,B7
3	AA, BA, CA, DA, M... (I, K, A, B, D...)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	18	Chemie (NAG)

Sequence modifications

A, B, D, F, I, K: 18 - 220 (UniProt: Q8QN22)

PDB	External Database	Details
Lys 15	-	expression tag
Pro 16	-	expression tag
Glu 17	-	expression tag
Gly 221	-	expression tag
Ser 222	-	expression tag
Thr 223	-	expression tag
Gly 224	-	expression tag
Gly 225	-	expression tag
Ser 226	-	expression tag
Glu 227	-	expression tag
Asn 228	-	expression tag
Leu 229	-	expression tag
Tyr 230	-	expression tag
Phe 231	-	expression tag
Gln 232	-	expression tag
Gly 233	-	expression tag
His 234	-	expression tag
His 235	-	expression tag
His 236	-	expression tag
His 237	-	expression tag
His 238	-	expression tag
His 239	-	expression tag

H, C, E, G, J, L: 1 - 201 (UniProt: P33681)

PDB	External Database	Details
Ala 200	Thr 234	conflict

Contents of the asymmetric unit

Polymers	Number of chains	12
	Total formula weight	292818.2
Non-Polymers*	Number of molecules	18
	Total formula weight	3981.7
All*	Total formula weight	296799.9

*Water molecules are not included.