8FW6
Human Lactate Dehydrogenase A in Complex with Inhibitor CHK-336
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | L-lactate dehydrogenase A chain | polymer | 338 | 37563.5 | 2 | UniProt (P00338) Pfam (PF00056) Pfam (PF02866) | Homo sapiens (human) | LDH-A,Cell proliferation-inducing gene 19 protein,LDH muscle subunit,LDH-M,Renal carcinoma antigen NY-REN-59 |
| 2 | C, P (A, B) | 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE | non-polymer | 665.4 | 2 | Chemie (NAI) | |||
| 3 | D, Q (A, B) | (2P)-2-{5-(cyclopropylmethyl)-3-(4-fluorophenyl)-4-[(3-fluoro-4-sulfamoylphenyl)methyl]-1H-pyrazol-1-yl}-1,3-thiazole-4-carboxylic acid | non-polymer | 530.6 | 2 | Chemie (YBO) | |||
| 4 | E, F, G, H, I... (A, B) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 17 | Chemie (EDO) | |||
| 5 | R (B) | DI(HYDROXYETHYL)ETHER | non-polymer | 106.1 | 1 | Chemie (PEG) | |||
| 6 | Y, Z (A, B) | water | water | 18.0 | 324 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 332 (UniProt: P00338)
| PDB | External Database | Details |
|---|---|---|
| His 333 | - | expression tag |
| His 334 | - | expression tag |
| His 335 | - | expression tag |
| His 336 | - | expression tag |
| His 337 | - | expression tag |
| His 338 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 75127.1 | |
| Non-Polymers* | Number of molecules | 22 |
| Total formula weight | 3553.3 | |
| All* | Total formula weight | 78680.4 |
