8FVJ

Dimeric form of HIV-1 Vif in complex with human CBF-beta, ELOB, ELOC, and CUL5

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, F (0, 5)	Core-binding factor subunit beta	polymer	157	18643.8	2	UniProt (Q13951) Pfam (PF02312)	Homo sapiens (human)	CBF-beta,Polyomavirus enhancer-binding protein 2 beta subunit,PEA2-beta,PEBP2-beta,SL3-3 enhancer factor 1 subunit beta,SL3/AKV core-binding factor beta subunit
2	B, G (1, 6)	Virion infectivity factor	polymer	178	21160.5	2	UniProt (P12504)	Human immunodeficiency virus 1	Vif,SOR protein
3	C, H (3, 8)	Elongin-B	polymer	102	11488.0	2	UniProt (Q15370) Pfam (PF00240)	Homo sapiens (human)	EloB,Elongin 18 kDa subunit,RNA polymerase II transcription factor SIII subunit B,SIII p18,Transcription elongation factor B polypeptide 2
4	D, I (4, 9)	Elongin-C	polymer	96	10843.4	2	UniProt (Q15369) Pfam (PF03931)	Homo sapiens (human)	EloC, Elongin 15 kDa subunit, RNA polymerase II transcription factor SIII subunit C, SIII p15, Transcription elongation factor B polypeptide 1
5	E, J (2, 7)	Cullin-5	polymer	314	36614.0	2	UniProt (Q93034) Pfam (PF00888)	Homo sapiens (human)	CUL-5,Vasopressin-activated calcium-mobilizing receptor 1,VACM-1
6	K, L (1, 6)	ZINC ION	non-polymer		65.4	2	Chemie (ZN)

Sequence modifications

1, 6: 1 - 177 (UniProt: P12504)

PDB	External Database	Details
Gly -1	-	expression tag
Pro 0	-	expression tag
His 48	Asn 48	conflict

2, 7: 10 - 320 (UniProt: Q93034)

PDB	External Database	Details
Gly 7	-	expression tag
Pro 8	-	expression tag
Ala 9	-	expression tag
Ser 11	-	insertion

Contents of the asymmetric unit

Polymers	Number of chains	10
	Total formula weight	197499.4
Non-Polymers*	Number of molecules	2
	Total formula weight	130.8
All*	Total formula weight	197630.2

*Water molecules are not included.