8FVJ
Dimeric form of HIV-1 Vif in complex with human CBF-beta, ELOB, ELOC, and CUL5
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| 0 | 0003713 | molecular_function | transcription coactivator activity |
| 0 | 0005634 | cellular_component | nucleus |
| 1 | 0003723 | molecular_function | RNA binding |
| 1 | 0005515 | molecular_function | protein binding |
| 1 | 0016020 | cellular_component | membrane |
| 1 | 0019058 | biological_process | viral life cycle |
| 1 | 0020002 | cellular_component | host cell plasma membrane |
| 1 | 0030430 | cellular_component | host cell cytoplasm |
| 1 | 0044423 | cellular_component | virion component |
| 2 | 0006511 | biological_process | ubiquitin-dependent protein catabolic process |
| 2 | 0031625 | molecular_function | ubiquitin protein ligase binding |
| 3 | 0006368 | biological_process | transcription elongation by RNA polymerase II |
| 3 | 0030891 | cellular_component | VCB complex |
| 3 | 0070449 | cellular_component | elongin complex |
| 4 | 0006511 | biological_process | ubiquitin-dependent protein catabolic process |
| 5 | 0003713 | molecular_function | transcription coactivator activity |
| 5 | 0005634 | cellular_component | nucleus |
| 6 | 0003723 | molecular_function | RNA binding |
| 6 | 0005515 | molecular_function | protein binding |
| 6 | 0016020 | cellular_component | membrane |
| 6 | 0019058 | biological_process | viral life cycle |
| 6 | 0020002 | cellular_component | host cell plasma membrane |
| 6 | 0030430 | cellular_component | host cell cytoplasm |
| 6 | 0044423 | cellular_component | virion component |
| 7 | 0006511 | biological_process | ubiquitin-dependent protein catabolic process |
| 7 | 0031625 | molecular_function | ubiquitin protein ligase binding |
| 8 | 0006368 | biological_process | transcription elongation by RNA polymerase II |
| 8 | 0030891 | cellular_component | VCB complex |
| 8 | 0070449 | cellular_component | elongin complex |
| 9 | 0006511 | biological_process | ubiquitin-dependent protein catabolic process |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 6 |
| Details | Region: {"description":"Interaction with host APOBEC3F; F1-box","evidences":[{"source":"HAMAP-Rule","id":"MF_04081","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 8 |
| Details | Region: {"description":"Interaction with host APOBEC3G; G-box","evidences":[{"source":"HAMAP-Rule","id":"MF_04081","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 36 |
| Details | Region: {"description":"Interaction with host APOBEC3F and APOBEC3G; FG-box","evidences":[{"source":"HAMAP-Rule","id":"MF_04081","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | Region: {"description":"Membrane association","evidences":[{"source":"HAMAP-Rule","id":"MF_04081","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 62 |
| Details | Motif: {"description":"HCCH motif","evidences":[{"source":"HAMAP-Rule","id":"MF_04081","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 18 |
| Details | Motif: {"description":"BC-box-like motif","evidences":[{"source":"HAMAP-Rule","id":"MF_04081","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 8 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"24402281","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37640699","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4N9F","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8FVI","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 2 |
| Details | Site: {"description":"Cleavage in virion (by viral protease)","evidences":[{"source":"HAMAP-Rule","id":"MF_04081","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"12186895","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphothreonine; by host MAP4K1","evidences":[{"source":"HAMAP-Rule","id":"MF_04081","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphoserine; by host","evidences":[{"source":"HAMAP-Rule","id":"MF_04081","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphoserine; by host MAP4K1","evidences":[{"source":"HAMAP-Rule","id":"MF_04081","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI12 |
| Number of Residues | 130 |
| Details | Domain: {"description":"Ubiquitin-like","evidences":[{"source":"PROSITE-ProRule","id":"PRU00214","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI13 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"N-acetylmethionine","evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"MAR-2009","submissionDatabase":"UniProtKB","authors":["Bienvenut W.V.","Waridel P.","Quadroni M."]}},{"source":"PubMed","id":"19413330","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"22814378","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI14 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI15 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
