8FVI

Human APOBEC3H bound to HIV-1 Vif in complex with CBF-beta, ELOB, ELOC, and CUL5

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	0	Core-binding factor subunit beta	polymer	157	18643.8	1	UniProt (Q13951) Pfam (PF02312) In PDB	Homo sapiens (human)	CBF-beta,Polyomavirus enhancer-binding protein 2 beta subunit,PEA2-beta,PEBP2-beta,SL3-3 enhancer factor 1 subunit beta,SL3/AKV core-binding factor beta subunit
2	1	Virion infectivity factor	polymer	178	21160.5	1	UniProt (P12504) Pfam (PF00559) In PDB	Human immunodeficiency virus 1	Vif,SOR protein
3	A	DNA dC->dU-editing enzyme APOBEC-3H	polymer	189	22103.4	1	UniProt (Q6NTF7) Pfam (PF18771) In PDB	Homo sapiens (human)	APOBEC-related protein 10,ARP-10,Apolipoprotein B mRNA-editing enzyme catalytic polypeptide-like 3H,A3H
4	B	RNA(5'-R(AP*UP*UP*UP*UP*UP*UP*UP*UP*U)-3')	polymer	10	3039.7	1		Escherichia coli
5	C	RNA(5'-R(*AP*AP*AP*AP*AP*AP*AP*AP*A)-3')	polymer	9	2917.9	1		Escherichia coli
6	x	Cullin 5	polymer	314	36614.0	1	UniProt (A0A2K5ZN28) Pfam (PF00888) UniProt (by SIFTS) (Q93034) In PDB	Homo sapiens (human)
7	y	Elongin-B	polymer	102	11488.0	1	UniProt (Q15370) Pfam (PF00240) In PDB	Homo sapiens (human)	EloB,Elongin 18 kDa subunit,RNA polymerase II transcription factor SIII subunit B,SIII p18,Transcription elongation factor B polypeptide 2
8	z	Elongin-C	polymer	96	10843.4	1	UniProt (Q15369) Pfam (PF03931) In PDB	Homo sapiens (human)	EloC, Elongin 15 kDa subunit, RNA polymerase II transcription factor SIII subunit C, SIII p15, Transcription elongation factor B polypeptide 1
9	1, A	ZINC ION	non-polymer		65.4	2	Chemie (ZN)
10		water	water		18.0	1	Chemie (HOH)

Sequence modifications

1: 1 - 177 (UniProt: P12504)

PDB	External Database	Details
Gly -1	-	expression tag
Pro 0	-	expression tag
His 48	Asn 48	conflict

A: 1 - 181 (UniProt: Q6NTF7)

PDB	External Database	Details
Gly -6	-	expression tag
Pro -5	-	expression tag
Gly -4	-	expression tag
Gly -3	-	expression tag
Ser -2	-	expression tag
Gly -1	-	expression tag
Gly 0	-	expression tag
Gln 97	Lys 97	conflict
Arg 105	Gly 105	variant
Asp 121	Lys 121	conflict
Asp 178	Glu 178	variant
Ser 182	-	expression tag

x: 11 - 320 (UniProt: A0A2K5ZN28)

PDB	External Database	Details
Gly 7	-	expression tag
Pro 8	-	expression tag
Ala 9	-	expression tag
Gly 10	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	8
	Total formula weight	126810.7
Non-Polymers*	Number of molecules	2
	Total formula weight	130.8
All*	Total formula weight	126941.6

*Water molecules are not included.