8FVI
Human APOBEC3H bound to HIV-1 Vif in complex with CBF-beta, ELOB, ELOC, and CUL5
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (0) | Core-binding factor subunit beta | polymer | 157 | 18643.8 | 1 | UniProt (Q13951) Pfam (PF02312) | Homo sapiens (human) | CBF-beta,Polyomavirus enhancer-binding protein 2 beta subunit,PEA2-beta,PEBP2-beta,SL3-3 enhancer factor 1 subunit beta,SL3/AKV core-binding factor beta subunit |
| 2 | B (1) | Virion infectivity factor | polymer | 178 | 21160.5 | 1 | UniProt (P12504) Pfam (PF00559) | Human immunodeficiency virus 1 | Vif,SOR protein |
| 3 | C (A) | DNA dC->dU-editing enzyme APOBEC-3H | polymer | 189 | 22103.4 | 1 | UniProt (Q6NTF7) Pfam (PF18771) | Homo sapiens (human) | APOBEC-related protein 10,ARP-10,Apolipoprotein B mRNA-editing enzyme catalytic polypeptide-like 3H,A3H |
| 4 | D (B) | RNA(5'-R(AP*UP*UP*UP*UP*UP*UP*UP*UP*U)-3') | polymer | 10 | 3039.7 | 1 | Escherichia coli | ||
| 5 | E (C) | RNA(5'-R(*AP*AP*AP*AP*AP*AP*AP*AP*A)-3') | polymer | 9 | 2917.9 | 1 | Escherichia coli | ||
| 6 | F (x) | Cullin 5 | polymer | 314 | 36614.0 | 1 | UniProt (A0A2K5ZN28) Pfam (PF00888) UniProt (by SIFTS) (Q93034) | Homo sapiens (human) | |
| 7 | G (y) | Elongin-B | polymer | 102 | 11488.0 | 1 | UniProt (Q15370) Pfam (PF00240) | Homo sapiens (human) | EloB,Elongin 18 kDa subunit,RNA polymerase II transcription factor SIII subunit B,SIII p18,Transcription elongation factor B polypeptide 2 |
| 8 | H (z) | Elongin-C | polymer | 96 | 10843.4 | 1 | UniProt (Q15369) Pfam (PF03931) | Homo sapiens (human) | EloC, Elongin 15 kDa subunit, RNA polymerase II transcription factor SIII subunit C, SIII p15, Transcription elongation factor B polypeptide 1 |
| 9 | I, J (1, A) | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
| 10 | K (A) | water | water | 18.0 | 1 | Chemie (HOH) |
Sequence modifications
1: 1 - 177 (UniProt: P12504)
A: 1 - 181 (UniProt: Q6NTF7)
x: 11 - 320 (UniProt: A0A2K5ZN28)
| PDB | External Database | Details |
|---|---|---|
| Gly -1 | - | expression tag |
| Pro 0 | - | expression tag |
| His 48 | Asn 48 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Gly -6 | - | expression tag |
| Pro -5 | - | expression tag |
| Gly -4 | - | expression tag |
| Gly -3 | - | expression tag |
| Ser -2 | - | expression tag |
| Gly -1 | - | expression tag |
| Gly 0 | - | expression tag |
| Gln 97 | Lys 97 | conflict |
| Arg 105 | Gly 105 | variant |
| Asp 121 | Lys 121 | conflict |
| Asp 178 | Glu 178 | variant |
| Ser 182 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Gly 7 | - | expression tag |
| Pro 8 | - | expression tag |
| Ala 9 | - | expression tag |
| Gly 10 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 8 |
| Total formula weight | 126810.7 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 130.8 | |
| All* | Total formula weight | 126941.6 |
