8FPX
Crystal structure of tumor related RhoA mutant A161P in complex with GDP
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Transforming protein RhoA | polymer | 183 | 20604.6 | 1 | UniProt (P61586) Pfam (PF00071) In PDB | Homo sapiens (human) | Rho cDNA clone 12,h12 |
| 2 | A | GUANOSINE-5'-DIPHOSPHATE | non-polymer | 443.2 | 1 | Chemie (GDP) | |||
| 3 | A | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) | |||
| 4 | A | 1,4-DIETHYLENE DIOXIDE | non-polymer | 88.1 | 1 | Chemie (DIO) | |||
| 5 | water | water | 18.0 | 197 | Chemie (HOH) |
Sequence modifications
A: 1 - 181 (UniProt: P61586)
| PDB | External Database | Details |
|---|---|---|
| Gly -1 | - | expression tag |
| Ser 0 | - | expression tag |
| Asn 25 | Phe 25 | engineered mutation |
| Pro 161 | Ala 161 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 20604.6 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 555.6 | |
| All* | Total formula weight | 21160.2 |
