8FPI
Co-structure of the Respiratory Syncytial Virus RNA-dependent RNA polymerase with MRK-1
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | RNA-directed RNA polymerase L | polymer | 1497 | 173267.9 | 1 | UniProt (P28887) Pfam (PF00946) Pfam (PF14318) | Human respiratory syncytial virus A2 | Protein L,Large structural protein,Replicase,Transcriptase |
| 2 | B, C, D, E (B, C, D, E) | Phosphoprotein | polymer | 256 | 29062.9 | 4 | UniProt (P03421) Pfam (PF02478) | Human respiratory syncytial virus A2 | Protein P |
| 3 | F (A) | 4-(2-aminopropan-2-yl)-N'-[4-(cyclopropyloxy)-3-methoxybenzoyl]-6-(4-fluorophenyl)pyridine-2-carbohydrazide | non-polymer | 478.5 | 1 | Chemie (Y6L) |
Sequence modifications
A: 1 - 1460 (UniProt: P28887)
B, C, D, E: 1 - 241 (UniProt: P03421)
| PDB | External Database | Details |
|---|---|---|
| Met -36 | - | initiating methionine |
| Gly -35 | - | expression tag |
| Ser -34 | - | expression tag |
| Asp -33 | - | expression tag |
| Tyr -32 | - | expression tag |
| Lys -31 | - | expression tag |
| Asp -30 | - | expression tag |
| His -29 | - | expression tag |
| Asp -28 | - | expression tag |
| Gly -27 | - | expression tag |
| Asp -26 | - | expression tag |
| Tyr -25 | - | expression tag |
| Lys -24 | - | expression tag |
| Asp -23 | - | expression tag |
| His -22 | - | expression tag |
| Asp -21 | - | expression tag |
| Ile -20 | - | expression tag |
| Asp -19 | - | expression tag |
| Tyr -18 | - | expression tag |
| Lys -17 | - | expression tag |
| Asp -16 | - | expression tag |
| Asp -15 | - | expression tag |
| Asp -14 | - | expression tag |
| Asp -13 | - | expression tag |
| Lys -12 | - | expression tag |
| Gly -11 | - | expression tag |
| Ser -10 | - | expression tag |
| Gly -9 | - | expression tag |
| Ser -8 | - | expression tag |
| Leu -7 | - | expression tag |
| Glu -6 | - | expression tag |
| Val -5 | - | expression tag |
| Leu -4 | - | expression tag |
| Phe -3 | - | expression tag |
| Gln -2 | - | expression tag |
| Gly -1 | - | expression tag |
| Pro 0 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Lys 242 | - | expression tag |
| Gly 243 | - | expression tag |
| Glu 244 | - | expression tag |
| Asn 245 | - | expression tag |
| Lys 246 | - | expression tag |
| Tyr 247 | - | expression tag |
| Phe 248 | - | expression tag |
| Gln 249 | - | expression tag |
| Gly 250 | - | expression tag |
| His 251 | - | expression tag |
| His 252 | - | expression tag |
| His 253 | - | expression tag |
| His 254 | - | expression tag |
| His 255 | - | expression tag |
| His 256 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 5 |
| Total formula weight | 289519.5 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 478.5 | |
| All* | Total formula weight | 289998.0 |
