8FPI

Co-structure of the Respiratory Syncytial Virus RNA-dependent RNA polymerase with MRK-1

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003968	molecular_function	RNA-directed RNA polymerase activity
A	0004482	molecular_function	mRNA 5'-cap (guanine-N7-)-methyltransferase activity
A	0005524	molecular_function	ATP binding
A	0006370	biological_process	7-methylguanosine mRNA capping
B	0001172	biological_process	RNA-templated transcription
B	0003968	molecular_function	RNA-directed RNA polymerase activity
B	0005515	molecular_function	protein binding
B	0019058	biological_process	viral life cycle
B	0030430	cellular_component	host cell cytoplasm
B	0044423	cellular_component	virion component
B	0085034	biological_process	symbiont-mediated suppression of host NF-kappaB cascade
C	0001172	biological_process	RNA-templated transcription
C	0003968	molecular_function	RNA-directed RNA polymerase activity
C	0005515	molecular_function	protein binding
C	0019058	biological_process	viral life cycle
C	0030430	cellular_component	host cell cytoplasm
C	0044423	cellular_component	virion component
C	0085034	biological_process	symbiont-mediated suppression of host NF-kappaB cascade
D	0001172	biological_process	RNA-templated transcription
D	0003968	molecular_function	RNA-directed RNA polymerase activity
D	0005515	molecular_function	protein binding
D	0019058	biological_process	viral life cycle
D	0030430	cellular_component	host cell cytoplasm
D	0044423	cellular_component	virion component
D	0085034	biological_process	symbiont-mediated suppression of host NF-kappaB cascade
E	0001172	biological_process	RNA-templated transcription
E	0003968	molecular_function	RNA-directed RNA polymerase activity
E	0005515	molecular_function	protein binding
E	0019058	biological_process	viral life cycle
E	0030430	cellular_component	host cell cytoplasm
E	0044423	cellular_component	virion component
E	0085034	biological_process	symbiont-mediated suppression of host NF-kappaB cascade

Functional Information from PROSITE/UniProt

site_id	PS00290
Number of Residues	7
Details	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YGCIVYH

Chain	Residue	Details
A	TYR249-HIS255

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	184
Details	Domain: {"description":"RdRp catalytic","evidences":[{"source":"PROSITE-ProRule","id":"PRU00539","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	492
Details	Region: {"description":"GDP polyribonucleotidyltransferase","evidences":[{"source":"PubMed","id":"31495574","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	Active site: {"description":"Nucleophile; for GDP polyribonucleotidyltransferase activity","evidences":[{"source":"UniProtKB","id":"P03523","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"31495574","evidenceCode":"ECO:0000303"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"31953395","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	10
Details	Compositional bias: {"description":"Basic and acidic residues","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	10
Details	Compositional bias: {"description":"Polar residues","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

---