8FMK

Crystal structure of human KRAS with extended switch I loop

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	GTPase KRas	polymer	176	20273.8	1	UniProt (P01116) Pfam (PF00071) In PDB	Homo sapiens (human)	K-Ras 2,Ki-Ras,c-K-ras,c-Ki-ras
2	A	GUANOSINE-5'-DIPHOSPHATE	non-polymer		443.2	1	Chemie (GDP)
3	A	MAGNESIUM ION	non-polymer		24.3	1	Chemie (MG)
4	A	CHLORIDE ION	non-polymer		35.5	2	Chemie (CL)
5		water	water		18.0	196	Chemie (HOH)

Sequence modifications

A: 1 - 169 (UniProt: P01116)

PDB	External Database	Details
Met -6	-	initiating methionine
His -5	-	expression tag
His -4	-	expression tag
His -3	-	expression tag
His -2	-	expression tag
His -1	-	expression tag
His 0	-	expression tag
Asp 12	Gly 12	variant
Ser 118	Cys 118	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	20273.8
Non-Polymers*	Number of molecules	4
	Total formula weight	538.4
All*	Total formula weight	20812.2

*Water molecules are not included.