8FJM
Crystal Structure of the Trypanosoma brucei DOT1A histone H3K76 methyltransferase in complex with AdoHcy - P212121 space group
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | Histone-lysine N-methyltransferase, H3 lysine-79 specific | polymer | 257 | 29325.8 | 2 | UniProt (Q581Z0) Pfam (PF08123) In PDB | Trypanosoma brucei brucei TREU927 | Histone H3-K79 methyltransferase, DOT1A |
| 2 | A, B | S-ADENOSYL-L-HOMOCYSTEINE | non-polymer | 384.4 | 2 | Chemie (SAH) | |||
| 3 | A, B | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
| 4 | A, B | CALCIUM ION | non-polymer | 40.1 | 2 | Chemie (CA) | |||
| 5 | B | ACETATE ION | non-polymer | 59.0 | 1 | Chemie (ACT) | |||
| 6 | water | water | 18.0 | 353 | Chemie (HOH) |
Sequence modifications
A, B: 43 - 295 (UniProt: Q581Z0)
| PDB | External Database | Details |
|---|---|---|
| Gly 39 | - | expression tag |
| Pro 40 | - | expression tag |
| His 41 | - | expression tag |
| Met 42 | - | expression tag |
| Ser 187 | Pro 187 | variant |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 58651.5 | |
| Non-Polymers* | Number of molecules | 7 |
| Total formula weight | 1038.8 | |
| All* | Total formula weight | 59690.4 |
