8FHT
Cryo-EM structure of human NCC
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Solute carrier family 12 member 3 | polymer | 1021 | 113279.7 | 2 | UniProt (P55017) Pfam (PF08403) Pfam (PF00324) Pfam (PF03522) | Homo sapiens (human) | Na-Cl cotransporter,NCC,Na-Cl symporter,Thiazide-sensitive sodium-chloride cotransporter |
| 2 | C, E (A, B) | SODIUM ION | non-polymer | 23.0 | 2 | Chemie (NA) | |||
| 3 | D, F (A, B) | CHLORIDE ION | non-polymer | 35.5 | 2 | Chemie (CL) |
Sequence modifications
A, B: 1 - 1021 (UniProt: P55017)
| PDB | External Database | Details |
|---|---|---|
| Asp 55 | Thr 55 | engineered mutation |
| Asp 60 | Thr 60 | engineered mutation |
| Asp 73 | Ser 73 | engineered mutation |
| Asn 140 | Lys 140 | engineered mutation |
| Gly 264 | Ala 264 | variant |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 226559.4 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 116.9 | |
| All* | Total formula weight | 226676.3 |
