8FHT
Cryo-EM structure of human NCC
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | Solute carrier family 12 member 3 | polymer | 1021 | 113279.7 | 2 | UniProt (P55017) Pfam (PF08403) Pfam (PF00324) Pfam (PF03522) In PDB | Homo sapiens (human) | Na-Cl cotransporter,NCC,Na-Cl symporter,Thiazide-sensitive sodium-chloride cotransporter |
2 | A, B | SODIUM ION | non-polymer | 23.0 | 2 | Chemie (NA) | |||
3 | A, B | CHLORIDE ION | non-polymer | 35.5 | 2 | Chemie (CL) |
Sequence modifications
A, B: 1 - 1021 (UniProt: P55017)
PDB | External Database | Details |
---|---|---|
Asp 55 | Thr 55 | engineered mutation |
Asp 60 | Thr 60 | engineered mutation |
Asp 73 | Ser 73 | engineered mutation |
Asn 140 | Lys 140 | engineered mutation |
Gly 264 | Ala 264 | variant |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 226559.4 | |
Non-Polymers* | Number of molecules | 4 |
Total formula weight | 116.9 | |
All* | Total formula weight | 226676.3 |