8FHO
Cryo-EM structure of human NCC (class 1)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C (A, B, C) | Solute carrier family 12 member 2,Solute carrier family 12 member 3 chimera | polymer | 1092 | 120372.2 | 3 | UniProt (A0A0G2KTI4) UniProt (P55017) Pfam (PF08403) Pfam (PF00324) Pfam (PF03522) | Danio rerio (Zebrafish Brachydanio rerio) | Na-K-Cl cotransporter 1,Na-Cl cotransporter,NCC,Na-Cl symporter,Thiazide-sensitive sodium-chloride cotransporter |
| 2 | D, G (A, B) | ADENOSINE-5'-TRIPHOSPHATE | non-polymer | 507.2 | 2 | Chemie (ATP) | |||
| 3 | E, H (A, B) | Polythiazide | non-polymer | 439.9 | 2 | Chemie (XZF) | |||
| 4 | F, I (A, B) | SODIUM ION | non-polymer | 23.0 | 2 | Chemie (NA) |
Sequence modifications
A, B, C: -70 - 131 (UniProt: A0A0G2KTI4)
A, B, C: null - 1021 (UniProt: P55017)
| PDB | External Database | Details |
|---|---|---|
| Lys 5 | Glu 76 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Ala 240 | Glu 240 | engineered mutation |
| Gly 264 | Ala 264 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 361116.5 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 1940.1 | |
| All* | Total formula weight | 363056.6 |
