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Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

8FHO

Cryo-EM structure of human NCC (class 1)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0006811	biological_process	monoatomic ion transport
A	0015377	molecular_function	chloride:monoatomic cation symporter activity
A	0016020	cellular_component	membrane
A	0022857	molecular_function	transmembrane transporter activity
A	0055085	biological_process	transmembrane transport
B	0006811	biological_process	monoatomic ion transport
B	0015377	molecular_function	chloride:monoatomic cation symporter activity
B	0016020	cellular_component	membrane
B	0022857	molecular_function	transmembrane transporter activity
B	0055085	biological_process	transmembrane transport
C	0006811	biological_process	monoatomic ion transport
C	0015377	molecular_function	chloride:monoatomic cation symporter activity
C	0016020	cellular_component	membrane
C	0022857	molecular_function	transmembrane transporter activity
C	0055085	biological_process	transmembrane transport

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	15
Details	MOD_RES: Phosphothreonine => ECO:0000250\|UniProtKB:P55013

Chain	Residue	Details
A	THR54
B	THR81
C	THR125
C	THR129
C	THR134
C	THR139
C	THR152
A	THR58
A	THR63
A	THR68
A	THR81
B	THR54
B	THR58
B	THR63
B	THR68

site_id	SWS_FT_FI2
Number of Residues	84
Details	TRANSMEM: Discontinuously helical => ECO:0000269\|PubMed:36351028, ECO:0000269\|PubMed:36792826, ECO:0007744\|PDB:7Y6I, ECO:0007744\|PDB:8FHN, ECO:0007744\|PDB:8FHO, ECO:0007744\|PDB:8FHP, ECO:0007744\|PDB:8FHQ, ECO:0007744\|PDB:8FHR, ECO:0007744\|PDB:8FHT

Chain	Residue	Details
A	VAL229-ILE257
B	VAL229-ILE257
C	VAL300-ILE328

site_id	SWS_FT_FI3
Number of Residues	297
Details	TOPO_DOM: Extracellular => ECO:0000269\|PubMed:36351028, ECO:0000269\|PubMed:36792826, ECO:0007744\|PDB:7Y6I, ECO:0007744\|PDB:8FHN, ECO:0007744\|PDB:8FHO, ECO:0007744\|PDB:8FHP, ECO:0007744\|PDB:8FHQ, ECO:0007744\|PDB:8FHR, ECO:0007744\|PDB:8FHT

Chain	Residue	Details
A	ASN258
B	LEU488-ASN544
B	SER615-VAL616
B	HIS676
C	ASN329
C	PHE412-PHE419
C	VAL468-CYS501
C	LEU559-ASN615
C	SER686-VAL687
C	HIS747
A	PHE341-PHE348
A	VAL397-CYS430
A	LEU488-ASN544
A	SER615-VAL616
A	HIS676
B	ASN258
B	PHE341-PHE348
B	VAL397-CYS430

site_id	SWS_FT_FI4
Number of Residues	807
Details	TRANSMEM: Helical => ECO:0000269\|PubMed:36351028, ECO:0000269\|PubMed:36792826, ECO:0007744\|PDB:7Y6I, ECO:0007744\|PDB:8FHN, ECO:0007744\|PDB:8FHO, ECO:0007744\|PDB:8FHP, ECO:0007744\|PDB:8FHQ, ECO:0007744\|PDB:8FHR, ECO:0007744\|PDB:8FHT

Chain	Residue	Details
A	ASP259-LYS284
A	ALA657-GLY675
A	VAL677-THR697
B	ASP259-LYS284
B	THR304-PHE340
B	PRO349-ALA368
B	ALA370-CYS396
B	THR431-SER451
B	THR458-GLN487
B	PHE545-ILE576
B	LEU597-SER614
A	THR304-PHE340
B	GLN617-CYS645
B	ALA657-GLY675
B	VAL677-THR697
C	ASP330-LYS355
C	THR375-PHE411
C	PRO420-ALA439
C	ALA441-CYS467
C	THR502-SER522
C	THR529-GLN558
C	PHE616-ILE647
A	PRO349-ALA368
C	LEU668-SER685
C	GLN688-CYS716
C	ALA728-GLY746
C	VAL748-THR768
A	ALA370-CYS396
A	THR431-SER451
A	THR458-GLN487
A	PHE545-ILE576
A	LEU597-SER614
A	GLN617-CYS645

site_id	SWS_FT_FI5
Number of Residues	1401
Details	TOPO_DOM: Cytoplasmic => ECO:0000269\|PubMed:36351028, ECO:0000269\|PubMed:36792826, ECO:0007744\|PDB:7Y6I, ECO:0007744\|PDB:8FHN, ECO:0007744\|PDB:8FHO, ECO:0007744\|PDB:8FHP, ECO:0007744\|PDB:8FHQ, ECO:0007744\|PDB:8FHR, ECO:0007744\|PDB:8FHT

Chain	Residue	Details
A	ALA285-GLY303
B	SER577-VAL596
B	LEU646-PRO656
C	ALA356-GLY374
C	ILE440
C	GLY523-ILE528
C	SER648-VAL667
C	LEU717-PRO727
A	ILE369
A	GLY452-ILE457
A	SER577-VAL596
A	LEU646-PRO656
B	ALA285-GLY303
B	ILE369
B	GLY452-ILE457

site_id	SWS_FT_FI6
Number of Residues	15
Details	BINDING: BINDING => ECO:0000269\|PubMed:36351028, ECO:0000269\|PubMed:36792826, ECO:0007744\|PDB:7Y6I, ECO:0007744\|PDB:8FHO, ECO:0007744\|PDB:8FHP, ECO:0007744\|PDB:8FHQ, ECO:0007744\|PDB:8FHR, ECO:0007744\|PDB:8FHT

Chain	Residue	Details
A	ALA239
B	ARG559
C	ALA310
C	VAL313
C	SER626
C	TRP629
C	ARG630
A	VAL242
A	SER555
A	TRP558
A	ARG559
B	ALA239
B	VAL242
B	SER555
B	TRP558

site_id	SWS_FT_FI7
Number of Residues	3
Details	BINDING: BINDING => ECO:0000269\|PubMed:36792826, ECO:0007744\|PDB:8FHO, ECO:0007744\|PDB:8FHP, ECO:0007744\|PDB:8FHQ, ECO:0007744\|PDB:8FHR

Chain	Residue	Details
A	ALA240
B	ALA240
C	ALA311

site_id	SWS_FT_FI8
Number of Residues	3
Details	BINDING: BINDING => ECO:0000269\|PubMed:36792826, ECO:0007744\|PDB:8FHO, ECO:0007744\|PDB:8FHP, ECO:0007744\|PDB:8FHQ

Chain	Residue	Details
A	PHE318
B	PHE318
C	PHE389

site_id	SWS_FT_FI9
Number of Residues	3
Details	BINDING: BINDING => ECO:0000269\|PubMed:36792826, ECO:0007744\|PDB:8FHN, ECO:0007744\|PDB:8FHO, ECO:0007744\|PDB:8FHP, ECO:0007744\|PDB:8FHQ, ECO:0007744\|PDB:8FHR

Chain	Residue	Details
A	PHE325
B	PHE325
C	PHE396

site_id	SWS_FT_FI10
Number of Residues	3
Details	BINDING: BINDING => ECO:0000269\|PubMed:36792826, ECO:0007744\|PDB:8FHN, ECO:0007744\|PDB:8FHP, ECO:0007744\|PDB:8FHR

Chain	Residue	Details
A	TYR443
B	TYR443
C	TYR514

site_id	SWS_FT_FI11
Number of Residues	12
Details	BINDING: BINDING => ECO:0000305\|PubMed:36351028, ECO:0000305\|PubMed:36792826

Chain	Residue	Details
A	TYR444
C	GLN516
C	THR517
C	LEU702
A	GLN445
A	THR446
A	LEU631
B	TYR444
B	GLN445
B	THR446
B	LEU631
C	TYR515

site_id	SWS_FT_FI12
Number of Residues	3
Details	BINDING: BINDING => ECO:0000269\|PubMed:36792826, ECO:0007744\|PDB:8FHN

Chain	Residue	Details
A	VAL450
B	VAL450
C	VAL521

site_id	SWS_FT_FI13
Number of Residues	18
Details	BINDING: BINDING => ECO:0000269\|PubMed:36792826, ECO:0007744\|PDB:8FHN, ECO:0007744\|PDB:8FHO

Chain	Residue	Details
A	VAL739
B	ASP832
B	ARG871
B	MET872
C	VAL810
C	TRP817
C	ASN839
C	ASP903
C	ARG942
C	MET943
A	TRP746
A	ASN768
A	ASP832
A	ARG871
A	MET872
B	VAL739
B	TRP746
B	ASN768

site_id	SWS_FT_FI14
Number of Residues	12
Details	MOD_RES: Phosphoserine => ECO:0000250\|UniProtKB:P59158

Chain	Residue	Details
A	VAL134
C	LYS211
C	ALA235
C	GLY288
A	LYS140
A	ALA164
A	GLY217
B	VAL134
B	LYS140
B	ALA164
B	GLY217
C	VAL205

site_id	SWS_FT_FI15
Number of Residues	9
Details	MOD_RES: Phosphothreonine; by OXSR1 and STK39 => ECO:0000269\|PubMed:18270262

Chain	Residue	Details
A	GLY137
A	CYS146
A	TRP151
B	GLY137
B	CYS146
B	TRP151
C	GLY208
C	CYS217
C	TRP222

site_id	SWS_FT_FI16
Number of Residues	6
Details	MOD_RES: Phosphothreonine => ECO:0000250\|UniProtKB:P59158

Chain	Residue	Details
A	GLY141
A	LEU215
B	GLY141
B	LEU215
C	GLY212
C	LEU286

site_id	SWS_FT_FI17
Number of Residues	3
Details	MOD_RES: Phosphoserine; by OXSR1 and STK39 => ECO:0000305\|PubMed:18270262, ECO:0007744\|PubMed:23186163

Chain	Residue	Details
A	THR182
B	THR182
C	THR253

site_id	SWS_FT_FI18
Number of Residues	6
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269\|PubMed:36351028, ECO:0007744\|PDB:7Y6I

Chain	Residue	Details
A	LYS497
A	VAL517
B	LYS497
B	VAL517
C	LYS568
C	VAL588

222415

PDB entries from 2024-07-10

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