8FHD
Cryo-EM structure of human voltage-gated sodium channel Nav1.6
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Sodium channel protein type 8 subunit alpha | polymer | 1980 | 225520.6 | 1 | UniProt (Q9UQD0) Pfam (PF00520) Pfam (PF11933) Pfam (PF06512) Pfam (PF00612) In PDB | Homo sapiens (human) | Sodium channel protein type VIII subunit alpha,Voltage-gated sodium channel subunit alpha Nav1.6 |
| 2 | C | Sodium channel subunit beta-1 | polymer | 218 | 24732.1 | 1 | UniProt (Q07699) Pfam (PF07686) In PDB | Homo sapiens (human) | |
| 3 | D | alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1559.4 | 1 | In PDB GlyTouCan (G83161QT) | |||
| 4 | F | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 1 | In PDB GlyTouCan (G42666HT) | |||
| 5 | C, A | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 7 | Chemie (NAG) | |||
| 6 | A | CHOLESTEROL HEMISUCCINATE | non-polymer | 486.7 | 4 | Chemie (Y01) | |||
| 7 | A | CHOLESTEROL | non-polymer | 386.7 | 1 | Chemie (CLR) | |||
| 8 | A | 1-O-OCTADECYL-SN-GLYCERO-3-PHOSPHOCHOLINE | non-polymer | 510.7 | 5 | Chemie (LPE) | |||
| 9 | A | 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE | non-polymer | 787.1 | 3 | Chemie (PCW) | |||
| 10 | A | O-[(R)-{[(2R)-2,3-bis(octadecanoyloxy)propyl]oxy}(hydroxy)phosphoryl]-L-serine | non-polymer | 792.1 | 2 | Chemie (P5S) | |||
| 11 | A | (3beta,14beta,17beta,25R)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en | non-polymer | 544.8 | 1 | Chemie (9Z9) | |||
| 12 | A | (5E,17R,20S)-23-amino-20-hydroxy-14,20-dioxo-15,19,21-trioxa-20lambda~5~-phosphatricos-5-en-17-yl hexadecanoate | non-polymer | 661.9 | 1 | Chemie (P3X) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 250252.7 | |
| Branched | Number of molecules | 2 |
| Total formula weight | 1983.8 | |
| Non-Polymers* | Number of molecules | 24 |
| Total formula weight | 11587.8 | |
| All* | Total formula weight | 263824.3 |
