8FE0

Human GAR transformylase in complex with GAR substrate and AGF305 inhibitor

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Phosphoribosylglycinamide formyltransferase	polymer	210	22753.1	1	UniProt (P22102) Pfam (PF00551) In PDB	Homo sapiens (human)	2-amino-N-ribosylacetamide 5'-phosphate transformylase
2	A	GLYCINAMIDE RIBONUCLEOTIDE	non-polymer		284.2	1	Chemie (GAR)
3	A	N-{5-[4-(2-amino-4-oxo-1,4-dihydrothieno[2,3-d]pyrimidin-6-yl)butyl]-3-fluoropyridine-2-carbonyl}-L-glutamic acid	non-polymer		491.5	1	Chemie (XSO)
4		water	water		18.0	106	Chemie (HOH)

Sequence modifications

A: 808 - 1010 (UniProt: P22102)

PDB	External Database	Details
Met 807	-	initiating methionine
Ala 905	Gln 905	conflict
His 1011	-	expression tag
His 1012	-	expression tag
His 1013	-	expression tag
His 1014	-	expression tag
His 1015	-	expression tag
His 1016	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	22753.1
Non-Polymers*	Number of molecules	2
	Total formula weight	775.7
All*	Total formula weight	23528.7

*Water molecules are not included.