8FE0
Human GAR transformylase in complex with GAR substrate and AGF305 inhibitor
Functional Information from GO Data
Functional Information from PROSITE/UniProt
| site_id | PS00373 |
| Number of Residues | 24 |
| Details | GART Phosphoribosylglycinamide formyltransferase active site. GcTVhFVaEdVDaGqiIlqeavpV |
| Chain | Residue | Details |
| A | GLY940-VAL963 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | ACT_SITE: Proton donor => ECO:0000250|UniProtKB:P08179 |
| Chain | Residue | Details |
| A | HIS915 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:12450384, ECO:0000269|PubMed:16026156, ECO:0007744|PDB:1MEN, ECO:0007744|PDB:1ZLY |
| Chain | Residue | Details |
| A | GLY818 | |
| A | LYS977 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000305|PubMed:12755606, ECO:0007744|PDB:1NJS |
| Chain | Residue | Details |
| A | ARG871 | |
| A | ASN913 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000305|PubMed:12755606, ECO:0000305|PubMed:16026156, ECO:0007744|PDB:1NJS, ECO:0007744|PDB:1ZLY |
| Chain | Residue | Details |
| A | MET896 | |
| A | ALA947 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | SITE: Raises pKa of active site His => ECO:0000250|UniProtKB:P08179 |
| Chain | Residue | Details |
| A | ASP951 |
