8FBH
Crystal structure of NSD1 Mutant-T1927A
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Histone-lysine N-methyltransferase, H3 lysine-36 specific | polymer | 232 | 26466.2 | 1 | UniProt (O88491) Pfam (PF17907) Pfam (PF00856) | Mus musculus (house mouse) | H3-K36-HMTase,Nuclear receptor-binding SET domain-containing protein 1,NR-binding SET domain-containing protein |
| 2 | B, C, D (A) | ZINC ION | non-polymer | 65.4 | 3 | Chemie (ZN) | |||
| 3 | E (A) | S-ADENOSYLMETHIONINE | non-polymer | 398.4 | 1 | Chemie (SAM) PubChem (58766358) PubChem (58633578) PubChem (87224684) PubChem (60038769) PubChem (131697735) PubChem (73897310) PubChem (5136) PubChem (145712080) PubChem (34755) PubChem (132988922) PubChem (9865603) PubChem (134692588) PubChem (135030730) PubChem (140459785) PubChem (12312798) PubChem (163046094) | |||
| 4 | F (A) | SULFATE ION | non-polymer | 96.1 | 1 | Chemie (SO4) | |||
| 5 | G, H, I (A) | UNKNOWN ATOM OR ION | non-polymer | 3 | Chemie (UNX) | ||||
| 6 | J (A) | water | water | 18.0 | 60 | Chemie (HOH) |
Sequence modifications
A: 1750 - 1980 (UniProt: O88491)
| PDB | External Database | Details |
|---|---|---|
| Gly 1749 | - | expression tag |
| Gly 1827 | Val 1827 | conflict |
| Glu 1841 | Asp 1841 | conflict |
| Ala 1927 | Thr 1927 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 26466.2 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 690.7 | |
| All* | Total formula weight | 27156.9 |
