8FBG
Crystal structure of NSD1 Mutant-Y1869C
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Histone-lysine N-methyltransferase, H3 lysine-36 specific | polymer | 232 | 26436.2 | 2 | UniProt (O88491) Pfam (PF17907) Pfam (PF00856) | Mus musculus (house mouse) | H3-K36-HMTase,Nuclear receptor-binding SET domain-containing protein 1,NR-binding SET domain-containing protein |
| 2 | C, D, E, I, J... (A, B) | ZINC ION | non-polymer | 65.4 | 7 | Chemie (ZN) | |||
| 3 | F, H, N, O (A, B) | CALCIUM ION | non-polymer | 40.1 | 4 | Chemie (CA) | |||
| 4 | G, M (A, B) | S-ADENOSYLMETHIONINE | non-polymer | 398.4 | 2 | Chemie (SAM) | |||
| 5 | P, Q (A, B) | water | water | 18.0 | 170 | Chemie (HOH) |
Sequence modifications
A, B: 1750 - 1980 (UniProt: O88491)
| PDB | External Database | Details |
|---|---|---|
| Gly 1749 | - | expression tag |
| Gly 1827 | Val 1827 | conflict |
| Glu 1841 | Asp 1841 | conflict |
| Cys 1869 | Tyr 1869 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 52872.4 | |
| Non-Polymers* | Number of molecules | 13 |
| Total formula weight | 1415.0 | |
| All* | Total formula weight | 54287.4 |
