8FAY
Human MUTYH adenine glycosylase bound to DNA containing a transition state analog (1N) paired with d(8-oxo-G)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, D (A, D) | Adenine DNA glycosylase | polymer | 459 | 50677.3 | 2 | UniProt (Q9UIF7) Pfam (PF00730) Pfam (PF00633) Pfam (PF14815) | Homo sapiens (human) | MutY homolog,hMYH |
| 2 | B, E (B, E) | DNA (5'-D(*AP*AP*GP*AP*CP*(8OG)P*TP*GP*GP*AP*C)-3') | polymer | 11 | 3423.2 | 2 | synthetic construct | ||
| 3 | C, F (C, F) | DNA (5'-D(P*GP*TP*CP*CP*AP*(NR1)P*GP*TP*CP*T)-3') | polymer | 11 | 3191.1 | 2 | synthetic construct | ||
| 4 | G, O (A, D) | IRON/SULFUR CLUSTER | non-polymer | 351.6 | 2 | Chemie (SF4) | |||
| 5 | H, I, J, K, L... (A, D, F) | SULFATE ION | non-polymer | 96.1 | 13 | Chemie (SO4) | |||
| 6 | AA, V, W, X, Y... (F, A, B, C, D...) | water | water | 18.0 | 463 | Chemie (HOH) |
Sequence modifications
A, D: 67 - 519 (UniProt: Q9UIF7)
| PDB | External Database | Details |
|---|---|---|
| Gly 61 | - | expression tag |
| His 62 | - | expression tag |
| Met 63 | - | expression tag |
| Ala 64 | - | expression tag |
| Cys 65 | - | expression tag |
| Asp 66 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 114583.3 | |
| Non-Polymers* | Number of molecules | 15 |
| Total formula weight | 1952.1 | |
| All* | Total formula weight | 116535.4 |
