8FAY

Human MUTYH adenine glycosylase bound to DNA containing a transition state analog (1N) paired with d(8-oxo-G)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003677	molecular_function	DNA binding
A	0003824	molecular_function	catalytic activity
A	0006281	biological_process	DNA repair
A	0006284	biological_process	base-excision repair
A	0016798	molecular_function	hydrolase activity, acting on glycosyl bonds
A	0051539	molecular_function	4 iron, 4 sulfur cluster binding
D	0003677	molecular_function	DNA binding
D	0003824	molecular_function	catalytic activity
D	0006281	biological_process	DNA repair
D	0006284	biological_process	base-excision repair
D	0016798	molecular_function	hydrolase activity, acting on glycosyl bonds
D	0051539	molecular_function	4 iron, 4 sulfur cluster binding

Functional Information from PROSITE/UniProt

site_id	PS00764
Number of Residues	17
Details	ENDONUCLEASE_III_1 Endonuclease III iron-sulfur binding region signature. CtpqRPLCsqCpveslC

Chain	Residue	Details
A	CYS290-CYS306

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site_id	PS01155
Number of Residues	31
Details	ENDONUCLEASE_III_2 Endonuclease III family signature. GhMPrtaetLqqlLPGVGrytAgaiAsiAFG

Chain	Residue	Details
A	GLY199-GLY229

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	44
Details	Motif: {"description":"Nudix box"}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	2
Details	Active site: {"description":"Proton donor/acceptor","evidences":[{"source":"UniProtKB","id":"P83847","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	8
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI4
Number of Residues	2
Details	Site: {"description":"Transition state stabilizer","evidences":[{"source":"UniProtKB","id":"P83847","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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