8F88
Crystal structure of PTP1B D181A/Q262A/C215A phosphatase domain with monophosphorylated JAK2 activation loop phosphopeptide
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C | Tyrosine-protein phosphatase non-receptor type 1 | polymer | 321 | 37232.5 | 3 | UniProt (P18031) Pfam (PF00102) In PDB | Homo sapiens (human) | Protein-tyrosine phosphatase 1B,PTP-1B |
| 2 | E, F, G | Tyrosine-protein kinase JAK2 | polymer | 16 | 2005.1 | 3 | UniProt (O60674) In PDB | Homo sapiens | Janus kinase 2,JAK-2 |
| 3 | A, C | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL | non-polymer | 122.1 | 3 | Chemie (TRS) | |||
| 4 | water | water | 18.0 | 37 | Chemie (HOH) |
Sequence modifications
A, B, C: 1 - 321 (UniProt: P18031)
| PDB | External Database | Details |
|---|---|---|
| Ala 181 | Asp 181 | engineered mutation |
| Ala 215 | Cys 215 | engineered mutation |
| Ala 262 | Gln 262 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 117713.0 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 366.4 | |
| All* | Total formula weight | 118079.4 |
