8F86
SIRT6 bound to an H3K9Ac nucleosome
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, E | Histone H3.2 | polymer | 135 | 15271.9 | 2 | UniProt (P84233) Pfam (PF00125) In PDB | Xenopus laevis (African clawed frog) | |
2 | B, F | Histone H4 | polymer | 102 | 11263.2 | 2 | UniProt (P62799) Pfam (PF15511) In PDB | Xenopus laevis (African clawed frog) | |
3 | C, G | Histone H2A type 1 | polymer | 129 | 13978.2 | 2 | UniProt (P06897) Pfam (PF00125) Pfam (PF16211) In PDB | Xenopus laevis (African clawed frog) | |
4 | D, H | Histone H2B | polymer | 122 | 13524.8 | 2 | UniProt (P02281) Pfam (PF00125) In PDB | Xenopus laevis (African clawed frog) | H2B1.1 |
5 | I | DNA (148-MER) | polymer | 185 | 57400.6 | 1 | synthetic construct | ||
6 | J | DNA (148-MER) | polymer | 185 | 56831.2 | 1 | synthetic construct | ||
7 | K | NAD-dependent protein deacylase sirtuin-6 | polymer | 355 | 39152.9 | 1 | UniProt (Q8N6T7) Pfam (PF02146) In PDB | Homo sapiens (human) | NAD-dependent protein deacetylase sirtuin-6,Protein mono-ADP-ribosyltransferase sirtuin-6,Regulatory protein SIR2 homolog 6,hSIRT6,SIR2-like protein 6 |
8 | A | [(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl [(3aR,5R,6R,6aR)-6-hydroxytetrahydro-2H-furo[2,3-d][1,3]oxathiol-5-yl]methyl dihydrogen diphosphate (non-preferred name) | non-polymer | 587.4 | 1 | Chemie (ZSL) | |||
9 | K | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) |
Sequence modifications
A, E: 1 - 135 (UniProt: P84233)
C, G: 1 - 129 (UniProt: P06897)
D, H: 1 - 122 (UniProt: P02281)
K: 2 - 355 (UniProt: Q8N6T7)
PDB | External Database | Details |
---|---|---|
Ala 102 | Gly 103 | conflict |
Ala 110 | Cys 111 | conflict |
PDB | External Database | Details |
---|---|---|
Arg 99 | Gly 100 | conflict |
Ser 123 | Ala 124 | conflict |
PDB | External Database | Details |
---|---|---|
Thr 29 | Ser 33 | variant |
PDB | External Database | Details |
---|---|---|
Cys 1 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 11 |
Total formula weight | 261460.8 | |
Non-Polymers* | Number of molecules | 2 |
Total formula weight | 652.8 | |
All* | Total formula weight | 262113.6 |