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8F7W

Gi bound kappa-opioid receptor in complex with dynorphin

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A
(R)
Kappa-type opioid receptorpolymer37842434.71UniProt (P41145)
Pfam (PF00001)
Homo sapiens (human)K-OR-1,KOR-1
2B
(P)
Dynorphinpolymer8983.21UniProt (P01213)Homo sapiens
3C
(A)
Guanine nucleotide-binding protein G(i) subunit alpha-1polymer35440445.11UniProt (P63096)
Pfam (PF00503)
Homo sapiens (human)Adenylate cyclase-inhibiting G alpha protein
4D
(B)
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1polymer35339020.71UniProt (P54311)
Pfam (PF00400)
Rattus norvegicus (Norway rat)Transducin beta chain 1
5E
(C)
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2polymer687563.81UniProt (P63212)
Pfam (PF00631)
Bos taurus (cattle)G gamma-I
6F
(E)
scFv16polymer24826408.51synthetic construct
7G, H, I
(R)
CHOLESTEROLnon-polymer386.73Chemie (CLR)
8J, K
(R)
PALMITIC ACIDnon-polymer256.42Chemie (PLM)
Sequence modifications
A: 1 - 354 (UniProt: P63096)
PDBExternal DatabaseDetails
Ala 203Gly 203conflict
Ser 326Ala 326conflict
B: 2 - 340 (UniProt: P54311)
PDBExternal DatabaseDetails
Met -12-expression tag
His -11-expression tag
His -10-expression tag
His -9-expression tag
His -8-expression tag
His -7-expression tag
His -6-expression tag
His -5-expression tag
His -4-expression tag
Gly -3-expression tag
Ser -2-expression tag
Leu -1-expression tag
Leu 0-expression tag
Gln 1-expression tag
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains6
Total formula weight156855.9
Non-Polymers*Number of molecules5
Total formula weight1672.8
All*Total formula weight158528.7
*Water molecules are not included.

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PDB entries from 2025-07-30

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