8F7D

LRRC8A(T48D):C conformation 2 top focus

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Volume-regulated anion channel subunit LRRC8A,Soluble cytochrome b562	polymer	911	105544.1	1	UniProt (Q80WG5) UniProt (P0ABE7) Pfam (PF12534) Pfam (PF07361) Pfam (PF13855)	Mus musculus (house mouse)	Leucine-rich repeat-containing protein 8A,Protein ebouriffe,ebo,Cytochrome b-562
2	B (F)	Volume-regulated anion channel subunit LRRC8C	polymer	813	93624.6	1	UniProt (Q8R502) Pfam (PF12534) Pfam (PF13855)	Mus musculus (house mouse)	Factor for adipocyte differentiation 158,Leucine-rich repeat-containing protein 8C

Sequence modifications

A: -91 - -16 (UniProt: Q80WG5)

PDB	External Database	Details
Asp -44	Thr 48	engineered mutation

A: -15 - 89 (UniProt: P0ABE7)

PDB	External Database	Details
Trp -9	Met 29	conflict
Ile 86	His 124	conflict

A: 90 - 810 (UniProt: Q80WG5)

PDB	External Database	Details
Leu 90	Pro 90	conflict
Ser 811	-	expression tag
Asn 812	-	expression tag
Ser 813	-	expression tag
Leu 814	-	expression tag
Glu 815	-	expression tag
Val 816	-	expression tag
Leu 817	-	expression tag
Phe 818	-	expression tag
Gln 819	-	expression tag

F: 1 - 803 (UniProt: Q8R502)

PDB	External Database	Details
Ser 804	-	expression tag
Asn 805	-	expression tag
Ser 806	-	expression tag
Glu 807	-	expression tag
Asn 808	-	expression tag
Leu 809	-	expression tag
Tyr 810	-	expression tag
Phe 811	-	expression tag
Gln 812	-	expression tag
Gly 813	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	199168.7
All*	Total formula weight	199168.7

*Water molecules are not included.