8F7D
LRRC8A(T48D):C conformation 2 top focus
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005506 | molecular_function | iron ion binding |
| A | 0009055 | molecular_function | electron transfer activity |
| A | 0020037 | molecular_function | heme binding |
| A | 0022900 | biological_process | electron transport chain |
| A | 0042597 | cellular_component | periplasmic space |
| A | 0046872 | molecular_function | metal ion binding |
| F | 0005225 | molecular_function | volume-sensitive anion channel activity |
| F | 0005737 | cellular_component | cytoplasm |
| F | 0005783 | cellular_component | endoplasmic reticulum |
| F | 0005789 | cellular_component | endoplasmic reticulum membrane |
| F | 0005886 | cellular_component | plasma membrane |
| F | 0015734 | biological_process | taurine transmembrane transport |
| F | 0015810 | biological_process | aspartate transmembrane transport |
| F | 0034214 | biological_process | protein hexamerization |
| F | 0034220 | biological_process | monoatomic ion transmembrane transport |
| F | 0034702 | cellular_component | monoatomic ion channel complex |
| F | 0045444 | biological_process | fat cell differentiation |
| F | 0055085 | biological_process | transmembrane transport |
| F | 0071470 | biological_process | cellular response to osmotic stress |
| F | 0098656 | biological_process | monoatomic anion transmembrane transport |
| F | 0140361 | biological_process | cyclic-GMP-AMP transmembrane import across plasma membrane |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 601 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000255 |
| Chain | Residue | Details |
| F | MET1-PRO22 | |
| F | LYS147-THR266 | |
| F | PHE342-ASP803 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 80 |
| Details | TRANSMEM: Helical => ECO:0000255 |
| Chain | Residue | Details |
| F | TRP23-CYS43 | |
| F | TYR126-PHE146 | |
| F | VAL267-VAL287 | |
| F | PHE321-LEU341 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 113 |
| Details | TOPO_DOM: Extracellular => ECO:0000255 |
| Chain | Residue | Details |
| F | THR44-LYS125 | |
| F | GLN288-SER320 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q8TDW0 |
| Chain | Residue | Details |
| F | SER212 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q498T9 |
| Chain | Residue | Details |
| F | SER215 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphothreonine => ECO:0007744|PubMed:21183079 |
| Chain | Residue | Details |
| A | THR200 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:21183079 |
| Chain | Residue | Details |
| A | SER202 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:Q8IWT6 |
| Chain | Residue | Details |
| A | THR215 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q8IWT6 |
| Chain | Residue | Details |
| A | SER217 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 1 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255 |
| Chain | Residue | Details |
| A | ASN-26 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 2 |
| Details | BINDING: axial binding residue |
| Chain | Residue | Details |
| A | TRP-9 | |
| A | ILE86 |
