8F6P
Rat Cardiac Sodium Channel with Ranolazine Bound
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Sodium channel protein type 5 subunit alpha,Green fluorescent protein | polymer | 1838 | 209096.9 | 1 | UniProt (P15389) UniProt (P42212) Pfam (PF00520) Pfam (PF06512) Pfam (PF01353) In PDB | Rattus norvegicus (Norway rat) | Sodium channel protein cardiac muscle subunit alpha,Sodium channel protein type V subunit alpha,Voltage-gated sodium channel subunit alpha Nav1.5, rNav1.5c |
2 | B, C | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 2 | In PDB GlyTouCan (G42666HT) | |||
3 | A | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 7 | Chemie (NAG) | |||
4 | A | beta-D-mannopyranose | non-polymer | 180.2 | 3 | Chemie (BMA) | |||
5 | A | (R)-ranolazine | non-polymer | 427.5 | 1 | Chemie (XHO) | |||
6 | A | [(2~{R})-1-[2-azanylethoxy(oxidanyl)phosphoryl]oxy-3-hexadecanoyloxy-propan-2-yl] (~{Z})-octadec-9-enoate | non-polymer | 718.0 | 6 | Chemie (6OU) | |||
7 | A | CHOLESTEROL HEMISUCCINATE | non-polymer | 486.7 | 13 | Chemie (Y01) |
Sequence modifications
A: 1 - 658 (UniProt: P15389)
A: 659 - 1189 (UniProt: P15389)
A: 1190 - 1898 (UniProt: P15389)
A: 1910 - 2146 (UniProt: P42212)
PDB | External Database | Details |
---|---|---|
Gln 347 | Glu 347 | conflict |
A: 1190 - 1898 (UniProt: P15389)
PDB | External Database | Details |
---|---|---|
Met 1499 | Ala 1446 | conflict |
Glu 1899 | - | linker |
Val 1900 | - | linker |
Leu 1901 | - | linker |
Phe 1902 | - | linker |
Gln 1903 | - | linker |
Gly 1904 | - | linker |
Pro 1905 | - | linker |
Gly 1906 | - | linker |
Ser 1907 | - | linker |
Met 1908 | - | linker |
Val 1909 | - | linker |
PDB | External Database | Details |
---|---|---|
Leu 1972 | Phe 64 | conflict |
Thr 1973 | Ser 65 | conflict |
Leu 2139 | His 231 | conflict |
Gly 2147 | - | expression tag |
Ser 2148 | - | expression tag |
Asp 2149 | - | expression tag |
Tyr 2150 | - | expression tag |
Lys 2151 | - | expression tag |
Asp 2152 | - | expression tag |
Asp 2153 | - | expression tag |
Asp 2154 | - | expression tag |
Asp 2155 | - | expression tag |
Lys 2156 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 209096.9 | |
Branched | Number of molecules | 2 |
Total formula weight | 848.8 | |
Non-Polymers* | Number of molecules | 30 |
Total formula weight | 13151.9 | |
All* | Total formula weight | 223097.6 |