8F6P
Rat Cardiac Sodium Channel with Ranolazine Bound
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Sodium channel protein type 5 subunit alpha,Green fluorescent protein | polymer | 1838 | 209096.9 | 1 | UniProt (P15389) UniProt (P42212) Pfam (PF00520) Pfam (PF06512) Pfam (PF01353) | Rattus norvegicus (Norway rat) | Sodium channel protein cardiac muscle subunit alpha,Sodium channel protein type V subunit alpha,Voltage-gated sodium channel subunit alpha Nav1.5, rNav1.5c |
| 2 | B, C (B, C) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 2 | In PDB GlyTouCan (G42666HT) | |||
| 3 | D, E, F, H, K... (A) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 7 | Chemie (NAG) | |||
| 4 | G, I, J (A) | beta-D-mannopyranose | non-polymer | 180.2 | 3 | Chemie (BMA) | |||
| 5 | N (A) | (R)-ranolazine | non-polymer | 427.5 | 1 | Chemie (XHO) | |||
| 6 | O, P, Q, R, S... (A) | [(2~{R})-1-[2-azanylethoxy(oxidanyl)phosphoryl]oxy-3-hexadecanoyloxy-propan-2-yl] (~{Z})-octadec-9-enoate | non-polymer | 718.0 | 6 | Chemie (6OU) | |||
| 7 | AA, BA, CA, DA, EA... (A) | CHOLESTEROL HEMISUCCINATE | non-polymer | 486.7 | 13 | Chemie (Y01) |
Sequence modifications
A: 1 - 658 (UniProt: P15389)
A: 659 - 1189 (UniProt: P15389)
A: 1190 - 1898 (UniProt: P15389)
A: 1910 - 2146 (UniProt: P42212)
| PDB | External Database | Details |
|---|---|---|
| Gln 347 | Glu 347 | conflict |
A: 1190 - 1898 (UniProt: P15389)
| PDB | External Database | Details |
|---|---|---|
| Met 1499 | Ala 1446 | conflict |
| Glu 1899 | - | linker |
| Val 1900 | - | linker |
| Leu 1901 | - | linker |
| Phe 1902 | - | linker |
| Gln 1903 | - | linker |
| Gly 1904 | - | linker |
| Pro 1905 | - | linker |
| Gly 1906 | - | linker |
| Ser 1907 | - | linker |
| Met 1908 | - | linker |
| Val 1909 | - | linker |
| PDB | External Database | Details |
|---|---|---|
| Leu 1972 | Phe 64 | conflict |
| Thr 1973 | Ser 65 | conflict |
| Leu 2139 | His 231 | conflict |
| Gly 2147 | - | expression tag |
| Ser 2148 | - | expression tag |
| Asp 2149 | - | expression tag |
| Tyr 2150 | - | expression tag |
| Lys 2151 | - | expression tag |
| Asp 2152 | - | expression tag |
| Asp 2153 | - | expression tag |
| Asp 2154 | - | expression tag |
| Asp 2155 | - | expression tag |
| Lys 2156 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 209096.9 | |
| Branched | Number of molecules | 2 |
| Total formula weight | 848.8 | |
| Non-Polymers* | Number of molecules | 30 |
| Total formula weight | 13151.9 | |
| All* | Total formula weight | 223097.6 |
