8F6P
Rat Cardiac Sodium Channel with Ranolazine Bound
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0001518 | cellular_component | voltage-gated sodium channel complex |
| A | 0005216 | molecular_function | monoatomic ion channel activity |
| A | 0005248 | molecular_function | voltage-gated sodium channel activity |
| A | 0005261 | molecular_function | monoatomic cation channel activity |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006091 | biological_process | generation of precursor metabolites and energy |
| A | 0006811 | biological_process | monoatomic ion transport |
| A | 0006814 | biological_process | sodium ion transport |
| A | 0008218 | biological_process | bioluminescence |
| A | 0016020 | cellular_component | membrane |
| A | 0055085 | biological_process | transmembrane transport |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 829 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000305 |
| Chain | Residue | Details |
| A | MET1-VAL130 | |
| A | ILE1526-ALA1583 | |
| A | LEU1636-GLY1644 | |
| A | PHE1696-CYS1705 | |
| A | GLY181-PHE189 | |
| A | LYS238-LYS250 | |
| A | MET415-LEU917 | |
| A | ALA771-TYR776 | |
| A | TRP823-ALA839 | |
| A | TYR1263-ILE1523 | |
| A | ALA1315-ARG1323 | |
| A | LEU1373-GLU1385 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 19 |
| Details | TRANSMEM: Helical; Name=S1 of repeat I => ECO:0000305|PubMed:31866066, ECO:0007744|PDB:6UZ0 |
| Chain | Residue | Details |
| A | HIS131-ALA150 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 298 |
| Details | TOPO_DOM: Extracellular => ECO:0000305 |
| Chain | Residue | Details |
| A | GLN151-THR158 | |
| A | TRP1347-ILE1352 | |
| A | TYR1411-PHE1455 | |
| A | GLN1478-MET1500 | |
| A | LEU1603-ILE1613 | |
| A | LEU1668-SER1674 | |
| A | PRO1735-LEU1752 | |
| A | ILE1770-TRP1800 | |
| A | VAL211-SER217 | |
| A | MET274-SER358 | |
| A | GLN380-GLY387 | |
| A | HIS739-GLU747 | |
| A | GLY798-VAL807 | |
| A | PHE862-PHE887 | |
| A | TRP907-GLN915 | |
| A | VAL1281-ASN1291 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 21 |
| Details | TRANSMEM: Helical; Name=S2 of repeat I => ECO:0000305|PubMed:31866066, ECO:0007744|PDB:6UZ0 |
| Chain | Residue | Details |
| A | LYS159-ARG180 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=S3 of repeat I => ECO:0000305|PubMed:31866066, ECO:0007744|PDB:6UZ0 |
| Chain | Residue | Details |
| A | LEU190-PHE210 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 19 |
| Details | TRANSMEM: Helical; Name=S4 of repeat I => ECO:0000305|PubMed:31866066, ECO:0007744|PDB:6UZ0 |
| Chain | Residue | Details |
| A | ALA218-LEU237 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 22 |
| Details | TRANSMEM: Helical; Name=S5 of repeat I => ECO:0000305|PubMed:31866066, ECO:0007744|PDB:6UZ0 |
| Chain | Residue | Details |
| A | LEU251-PHE273 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 75 |
| Details | INTRAMEM: Pore-forming => ECO:0000305|PubMed:31866066, ECO:0007744|PDB:6UZ0 |
| Chain | Residue | Details |
| A | PHE359-TYR379 | |
| A | PHE888-MET906 | |
| A | ILE1456-GLN1477 | |
| A | PHE1753-TYR1769 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 26 |
| Details | TRANSMEM: Helical; Name=S6 of repeat I => ECO:0000305|PubMed:31866066, ECO:0007744|PDB:6UZ0 |
| Chain | Residue | Details |
| A | LYS388-ALA414 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 17 |
| Details | TRANSMEM: Helical; Name=S1 of repeat II => ECO:0000305|PubMed:31866066, ECO:0007744|PDB:6UZ0 |
| Chain | Residue | Details |
| A | ASP721-GLU738 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 22 |
| Details | TRANSMEM: Helical; Name=S2 of repeat II => ECO:0000250|UniProtKB:D0E0C2 |
| Chain | Residue | Details |
| A | GLU748-ILE770 |
| site_id | SWS_FT_FI12 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=S3 of repeat II => ECO:0000250|UniProtKB:D0E0C2 |
| Chain | Residue | Details |
| A | TYR777-LEU797 |
| site_id | SWS_FT_FI13 |
| Number of Residues | 14 |
| Details | TRANSMEM: Helical; Name=S4 of repeat II => ECO:0000305|PubMed:31866066, ECO:0007744|PDB:6UZ0 |
| Chain | Residue | Details |
| A | LEU808-SER822 |
| site_id | SWS_FT_FI14 |
| Number of Residues | 21 |
| Details | TRANSMEM: Helical; Name=S5 of repeat II => ECO:0000250|UniProtKB:D0E0C2 |
| Chain | Residue | Details |
| A | LEU840-LEU861 |
| site_id | SWS_FT_FI15 |
| Number of Residues | 28 |
| Details | TRANSMEM: Helical; Name=S6 of repeat II => ECO:0000250|UniProtKB:D0E0C2 |
| Chain | Residue | Details |
| A | SER916-SER944 |
| site_id | SWS_FT_FI16 |
| Number of Residues | 21 |
| Details | TRANSMEM: Helical; Name=S1 of repeat III => ECO:0000250|UniProtKB:D0E0C2 |
| Chain | Residue | Details |
| A | LYS1259-ILE1280 |
| site_id | SWS_FT_FI17 |
| Number of Residues | 22 |
| Details | TRANSMEM: Helical; Name=S2 of repeat III => ECO:0000250|UniProtKB:D0E0C2 |
| Chain | Residue | Details |
| A | THR1292-ARG1314 |
| site_id | SWS_FT_FI18 |
| Number of Residues | 22 |
| Details | TRANSMEM: Helical; Name=S3 of repeat III => ECO:0000250|UniProtKB:D0E0C2 |
| Chain | Residue | Details |
| A | VAL1324-PHE1346 |
| site_id | SWS_FT_FI19 |
| Number of Residues | 19 |
| Details | TRANSMEM: Helical; Name=S4 of repeat III => ECO:0000250|UniProtKB:D0E0C2 |
| Chain | Residue | Details |
| A | MET1353-ASP1372 |
| site_id | SWS_FT_FI20 |
| Number of Residues | 24 |
| Details | TRANSMEM: Helical; Name=S5 of repeat III => ECO:0000250|UniProtKB:D0E0C2 |
| Chain | Residue | Details |
| A | CYS1386-GLY1410 |
| site_id | SWS_FT_FI21 |
| Number of Residues | 24 |
| Details | TRANSMEM: Helical; Name=S6 of repeat III => ECO:0000250|UniProtKB:D0E0C2 |
| Chain | Residue | Details |
| A | LYS1501-ASP1525 |
| site_id | SWS_FT_FI22 |
| Number of Residues | 18 |
| Details | TRANSMEM: Helical; Name=S1 of repeat IV => ECO:0000250|UniProtKB:D0E0C2 |
| Chain | Residue | Details |
| A | LEU1584-ILE1602 |
| site_id | SWS_FT_FI23 |
| Number of Residues | 21 |
| Details | TRANSMEM: Helical; Name=S2 of repeat IV => ECO:0000250|UniProtKB:D0E0C2 |
| Chain | Residue | Details |
| A | ILE1614-ILE1635 |
| site_id | SWS_FT_FI24 |
| Number of Residues | 22 |
| Details | TRANSMEM: Helical; Name=S3 of repeat IV => ECO:0000250|UniProtKB:D0E0C2 |
| Chain | Residue | Details |
| A | ILE1645-PHE1667 |
| site_id | SWS_FT_FI25 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=S4 of repeat IV => ECO:0000305|PubMed:31866066, ECO:0007744|PDB:6UZ0 |
| Chain | Residue | Details |
| A | ILE1675-ASN1695 |
| site_id | SWS_FT_FI26 |
| Number of Residues | 28 |
| Details | TRANSMEM: Helical; Name=S5 of repeat IV => ECO:0000305|PubMed:31866066, ECO:0007744|PDB:6UZ0 |
| Chain | Residue | Details |
| A | LEU1706-LEU1734 |
| site_id | SWS_FT_FI27 |
| Number of Residues | 25 |
| Details | TRANSMEM: Helical; Name=S6 of repeat IV => ECO:0000305|PubMed:31866066, ECO:0007744|PDB:6UZ0 |
| Chain | Residue | Details |
| A | GLU1801-PRO1826 |
| site_id | SWS_FT_FI28 |
| Number of Residues | 1 |
| Details | SITE: Cys residue near the selectivity filter, which has a free thiol that is susceptible to reaction with methanethiosulfonate (MTSET); Sodium current is irreversibly blocked by MTSET => ECO:0000250|UniProtKB:P04775, ECO:0000269|PubMed:26039939 |
| Chain | Residue | Details |
| A | CYS374 |
| site_id | SWS_FT_FI29 |
| Number of Residues | 8 |
| Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q14524 |
| Chain | Residue | Details |
| A | SER37 | |
| A | SER655 | |
| A | SER658 | |
| A | TYR695 | |
| A | LYS708 | |
| A | ILE769 | |
| A | SER665 | |
| A | SER668 |
| site_id | SWS_FT_FI30 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:Q14524 |
| Chain | Residue | Details |
| A | THR39 |
| site_id | SWS_FT_FI31 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:22673903 |
| Chain | Residue | Details |
| A | HIS681 | |
| A | ARG682 |
| site_id | SWS_FT_FI32 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphothreonine => ECO:0007744|PubMed:22673903 |
| Chain | Residue | Details |
| A | CYS684 |
| site_id | SWS_FT_FI33 |
| Number of Residues | 1 |
| Details | MOD_RES: Omega-N-methylarginine; alternate => ECO:0000250|UniProtKB:Q14524 |
| Chain | Residue | Details |
| A | ILE724 |
| site_id | SWS_FT_FI34 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q9JJV9 |
| Chain | Residue | Details |
| A | LEU737 |
| site_id | SWS_FT_FI35 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine; by PKC => ECO:0000250|UniProtKB:Q14524 |
| Chain | Residue | Details |
| A | LYS1558 |
| site_id | SWS_FT_FI36 |
| Number of Residues | 12 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255 |
| Chain | Residue | Details |
| A | ASN215 | |
| A | ALA1429 | |
| A | GLY1435 | |
| A | GLU1443 | |
| A | ASN284 | |
| A | ASN289 | |
| A | ASN292 | |
| A | ASN329 | |
| A | ASN741 | |
| A | ASN804 | |
| A | ASN865 | |
| A | PHE1420 |
| site_id | SWS_FT_FI37 |
| Number of Residues | 1 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:31866066, ECO:0007744|PDB:6UZ0, ECO:0007744|PDB:6UZ3 |
| Chain | Residue | Details |
| A | ASN319 |
| site_id | SWS_FT_FI38 |
| Number of Residues | 1 |
| Details | MOD_RES: (Z)-2,3-didehydrotyrosine => ECO:0000269|PubMed:8448132 |
| Chain | Residue | Details |
| A | TYR1974 |
| site_id | SWS_FT_FI39 |
| Number of Residues | 2 |
| Details | CROSSLNK: 5-imidazolinone (Ser-Gly) => ECO:0000269|PubMed:8448132 |
| Chain | Residue | Details |
| A | THR1973 | |
| A | GLY1975 |
