8F6P
Rat Cardiac Sodium Channel with Ranolazine Bound
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0001518 | cellular_component | voltage-gated sodium channel complex |
| A | 0003674 | molecular_function | molecular_function |
| A | 0005216 | molecular_function | monoatomic ion channel activity |
| A | 0005248 | molecular_function | voltage-gated sodium channel activity |
| A | 0005261 | molecular_function | monoatomic cation channel activity |
| A | 0005575 | cellular_component | cellular_component |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006091 | biological_process | generation of precursor metabolites and energy |
| A | 0006811 | biological_process | monoatomic ion transport |
| A | 0006814 | biological_process | sodium ion transport |
| A | 0008218 | biological_process | bioluminescence |
| A | 0016020 | cellular_component | membrane |
| A | 0055085 | biological_process | transmembrane transport |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 882 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000305 |
| Chain | Residue | Details |
| A | MET1-SER132 | |
| A | PHE1522-LEU1584 | |
| A | GLY1633-GLY1644 | |
| A | MET1693-THR1711 | |
| A | ARG180-PRO193 | |
| A | SER235-ASP253 | |
| A | VAL412-GLN915 | |
| A | ILE769-TRP782 | |
| A | TRP823-GLY838 | |
| A | TRP1260-ILE1526 | |
| A | PRO1312-VAL1325 | |
| A | ASP1372-SER1388 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 18 |
| Details | TRANSMEM: Helical; Name=S1 of repeat I => ECO:0000250|UniProtKB:D0E0C2 |
| Chain | Residue | Details |
| A | LEU133-GLN151 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 309 |
| Details | TOPO_DOM: Extracellular => ECO:0000305 |
| Chain | Residue | Details |
| A | HIS152-THR158 | |
| A | ILE1345-ILE1352 | |
| A | ALA1409-SER1460 | |
| A | GLY1483-MET1499 | |
| A | LEU1603-ILE1613 | |
| A | GLY1663-ILE1675 | |
| A | CYS1730-ILE1751 | |
| A | GLU1775-PHE1803 | |
| A | ASP212-SER217 | |
| A | MET274-SER358 | |
| A | ARG384-TYR390 | |
| A | GLU738-GLU748 | |
| A | GLY803-ASN804 | |
| A | GLY858-ASP886 | |
| A | ASP908-LEU920 | |
| A | ILE1280-THR1292 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=S2 of repeat I => ECO:0000250|UniProtKB:D0E0C2 |
| Chain | Residue | Details |
| A | LYS159-ALA179 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 17 |
| Details | TRANSMEM: Helical; Name=S3 of repeat I => ECO:0000250|UniProtKB:D0E0C2 |
| Chain | Residue | Details |
| A | TRP194-VAL211 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 16 |
| Details | TRANSMEM: Helical; Name=S4 of repeat I => ECO:0000250|UniProtKB:D0E0C2 |
| Chain | Residue | Details |
| A | ALA218-ILE234 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 19 |
| Details | TRANSMEM: Helical; Name=S5 of repeat I => ECO:0000250|UniProtKB:D0E0C2 |
| Chain | Residue | Details |
| A | VAL254-PHE273 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 87 |
| Details | INTRAMEM: Pore-forming => ECO:0000250|UniProtKB:D0E0C2 |
| Chain | Residue | Details |
| A | PHE359-LEU383 | |
| A | PHE887-TRP907 | |
| A | PHE1461-LEU1482 | |
| A | LEU1752-LEU1774 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=S6 of repeat I => ECO:0000250|UniProtKB:D0E0C2 |
| Chain | Residue | Details |
| A | MET391-ALA411 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 18 |
| Details | TRANSMEM: Helical; Name=S1 of repeat II => ECO:0000250|UniProtKB:D0E0C2 |
| Chain | Residue | Details |
| A | PHE719-LEU737 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 19 |
| Details | TRANSMEM: Helical; Name=S2 of repeat II => ECO:0000250|UniProtKB:D0E0C2 |
| Chain | Residue | Details |
| A | MET749-LYS768 |
| site_id | SWS_FT_FI12 |
| Number of Residues | 19 |
| Details | TRANSMEM: Helical; Name=S3 of repeat II => ECO:0000250|UniProtKB:D0E0C2 |
| Chain | Residue | Details |
| A | ASN783-MET802 |
| site_id | SWS_FT_FI13 |
| Number of Residues | 17 |
| Details | TRANSMEM: Helical; Name=S4 of repeat II => ECO:0000250|UniProtKB:D0E0C2 |
| Chain | Residue | Details |
| A | LEU805-SER822 |
| site_id | SWS_FT_FI14 |
| Number of Residues | 18 |
| Details | TRANSMEM: Helical; Name=S5 of repeat II => ECO:0000250|UniProtKB:D0E0C2 |
| Chain | Residue | Details |
| A | ALA839-VAL857 |
| site_id | SWS_FT_FI15 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=S6 of repeat II => ECO:0000250|UniProtKB:D0E0C2 |
| Chain | Residue | Details |
| A | VAL921-LEU941 |
| site_id | SWS_FT_FI16 |
| Number of Residues | 17 |
| Details | TRANSMEM: Helical; Name=S1 of repeat III => ECO:0000250|UniProtKB:D0E0C2 |
| Chain | Residue | Details |
| A | ALA1262-LEU1279 |
| site_id | SWS_FT_FI17 |
| Number of Residues | 18 |
| Details | TRANSMEM: Helical; Name=S2 of repeat III => ECO:0000250|UniProtKB:D0E0C2 |
| Chain | Residue | Details |
| A | LEU1293-ARG1311 |
| site_id | SWS_FT_FI18 |
| Number of Residues | 18 |
| Details | TRANSMEM: Helical; Name=S3 of repeat III => ECO:0000250|UniProtKB:D0E0C2 |
| Chain | Residue | Details |
| A | VAL1326-LEU1344 |
| site_id | SWS_FT_FI19 |
| Number of Residues | 18 |
| Details | TRANSMEM: Helical; Name=S4 of repeat III => ECO:0000250|UniProtKB:D0E0C2 |
| Chain | Residue | Details |
| A | MET1353-GLY1371 |
| site_id | SWS_FT_FI20 |
| Number of Residues | 19 |
| Details | TRANSMEM: Helical; Name=S5 of repeat III => ECO:0000250|UniProtKB:D0E0C2 |
| Chain | Residue | Details |
| A | PHE1389-GLY1408 |
| site_id | SWS_FT_FI21 |
| Number of Residues | 21 |
| Details | TRANSMEM: Helical; Name=S6 of repeat III => ECO:0000250|UniProtKB:D0E0C2 |
| Chain | Residue | Details |
| A | MET1500-GLY1521 |
| site_id | SWS_FT_FI22 |
| Number of Residues | 17 |
| Details | TRANSMEM: Helical; Name=S1 of repeat IV => ECO:0000250|UniProtKB:D0E0C2 |
| Chain | Residue | Details |
| A | ARG1585-ILE1602 |
| site_id | SWS_FT_FI23 |
| Number of Residues | 18 |
| Details | TRANSMEM: Helical; Name=S2 of repeat IV => ECO:0000250|UniProtKB:D0E0C2 |
| Chain | Residue | Details |
| A | ILE1614-ILE1632 |
| site_id | SWS_FT_FI24 |
| Number of Residues | 17 |
| Details | TRANSMEM: Helical; Name=S3 of repeat IV => ECO:0000250|UniProtKB:D0E0C2 |
| Chain | Residue | Details |
| A | ILE1645-ILE1662 |
| site_id | SWS_FT_FI25 |
| Number of Residues | 16 |
| Details | TRANSMEM: Helical; Name=S4 of repeat IV => ECO:0000250|UniProtKB:D0E0C2 |
| Chain | Residue | Details |
| A | PHE1676-ASP1692 |
| site_id | SWS_FT_FI26 |
| Number of Residues | 17 |
| Details | TRANSMEM: Helical; Name=S5 of repeat IV => ECO:0000250|UniProtKB:D0E0C2 |
| Chain | Residue | Details |
| A | SER1712-TYR1729 |
| site_id | SWS_FT_FI27 |
| Number of Residues | 22 |
| Details | TRANSMEM: Helical; Name=S6 of repeat IV => ECO:0000250|UniProtKB:D0E0C2 |
| Chain | Residue | Details |
| A | ASP1804-PRO1826 |
| site_id | SWS_FT_FI28 |
| Number of Residues | 1 |
| Details | SITE: Cys residue near the selectivity filter, which has a free thiol that is susceptible to reaction with methanethiosulfonate (MTSET); Sodium current is irreversibly blocked by MTSET => ECO:0000250|UniProtKB:P04775, ECO:0000269|PubMed:26039939 |
| Chain | Residue | Details |
| A | CYS374 |
| site_id | SWS_FT_FI29 |
| Number of Residues | 8 |
| Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q14524 |
| Chain | Residue | Details |
| A | SER37 | |
| A | SER655 | |
| A | SER658 | |
| A | TYR695 | |
| A | LYS708 | |
| A | ILE769 | |
| A | SER665 | |
| A | SER668 |
| site_id | SWS_FT_FI30 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:Q14524 |
| Chain | Residue | Details |
| A | THR39 |
| site_id | SWS_FT_FI31 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:22673903 |
| Chain | Residue | Details |
| A | HIS681 | |
| A | ARG682 |
| site_id | SWS_FT_FI32 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphothreonine => ECO:0007744|PubMed:22673903 |
| Chain | Residue | Details |
| A | CYS684 |
| site_id | SWS_FT_FI33 |
| Number of Residues | 1 |
| Details | MOD_RES: Omega-N-methylarginine; alternate => ECO:0000250|UniProtKB:Q14524 |
| Chain | Residue | Details |
| A | ILE724 |
| site_id | SWS_FT_FI34 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q9JJV9 |
| Chain | Residue | Details |
| A | LEU737 |
| site_id | SWS_FT_FI35 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine; by PKC => ECO:0000250|UniProtKB:Q14524 |
| Chain | Residue | Details |
| A | LYS1558 |
| site_id | SWS_FT_FI36 |
| Number of Residues | 13 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255 |
| Chain | Residue | Details |
| A | ASN215 | |
| A | PHE1420 | |
| A | ALA1429 | |
| A | GLY1435 | |
| A | GLU1443 | |
| A | ASN284 | |
| A | ASN289 | |
| A | ASN292 | |
| A | ASN319 | |
| A | ASN329 | |
| A | ASN741 | |
| A | ASN804 | |
| A | ASN865 |
| site_id | SWS_FT_FI37 |
| Number of Residues | 1 |
| Details | MOD_RES: (Z)-2,3-didehydrotyrosine => ECO:0000269|PubMed:8448132 |
| Chain | Residue | Details |
| A | TYR1974 |
| site_id | SWS_FT_FI38 |
| Number of Residues | 2 |
| Details | CROSSLNK: 5-imidazolinone (Ser-Gly) => ECO:0000269|PubMed:8448132 |
| Chain | Residue | Details |
| A | THR1973 | |
| A | GLY1975 |
