8EWY
Structure of Janus Kinase (JAK) dimer complexed with cytokine receptor intracellular domain
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | Tyrosine-protein kinase | polymer | 1173 | 136026.8 | 2 | UniProt (B1ASP2) Pfam (PF18379) Pfam (PF18377) Pfam (PF17887) Pfam (PF21990) Pfam (PF07714) UniProt (by SIFTS) (P52332) In PDB | Mus musculus (house mouse) | |
2 | C, D | Interferon lambda receptor 1 | polymer | 85 | 9895.4 | 2 | UniProt (Q8CGK5) In PDB | Mus musculus (house mouse) | IFN-lambda R1,Cytokine receptor class-II member 12,Cytokine receptor family 2 member 12,CRF2-12,Interleukin-28 receptor subunit alpha,IL-28 receptor subunit alpha,IL-28R-alpha,IL-28RA |
3 | A, B | ADENOSINE | non-polymer | 267.2 | 2 | Chemie (ADN) | |||
4 | A, B | ADENOSINE-5'-DIPHOSPHATE | non-polymer | 427.2 | 2 | Chemie (ADP) |
Sequence modifications
A, B: 1 - 1153 (UniProt: B1ASP2)
C, D: 249 - 298 (UniProt: Q8CGK5)
PDB | External Database | Details |
---|---|---|
Phe 657 | Val 657 | engineered mutation |
Gly 1154 | - | expression tag |
Ser 1155 | - | expression tag |
Asp 1156 | - | expression tag |
Arg 1157 | - | expression tag |
Lys 1158 | - | expression tag |
Ala 1159 | - | expression tag |
Ala 1160 | - | expression tag |
Val 1161 | - | expression tag |
Ser 1162 | - | expression tag |
His 1163 | - | expression tag |
Trp 1164 | - | expression tag |
Gln 1165 | - | expression tag |
His 1166 | - | expression tag |
His 1167 | - | expression tag |
His 1168 | - | expression tag |
His 1169 | - | expression tag |
His 1170 | - | expression tag |
His 1171 | - | expression tag |
His 1172 | - | expression tag |
His 1173 | - | expression tag |
PDB | External Database | Details |
---|---|---|
Gly 214 | - | expression tag |
Pro 215 | - | expression tag |
Arg 216 | - | expression tag |
Met 217 | - | expression tag |
Lys 218 | - | expression tag |
Gln 219 | - | expression tag |
Leu 220 | - | expression tag |
Glu 221 | - | expression tag |
Asp 222 | - | expression tag |
Lys 223 | - | expression tag |
Val 224 | - | expression tag |
Glu 225 | - | expression tag |
Glu 226 | - | expression tag |
Leu 227 | - | expression tag |
Leu 228 | - | expression tag |
Ser 229 | - | expression tag |
Lys 230 | - | expression tag |
Asn 231 | - | expression tag |
Tyr 232 | - | expression tag |
His 233 | - | expression tag |
Leu 234 | - | expression tag |
Glu 235 | - | expression tag |
Asn 236 | - | expression tag |
Glu 237 | - | expression tag |
Val 238 | - | expression tag |
Ala 239 | - | expression tag |
Arg 240 | - | expression tag |
Leu 241 | - | expression tag |
Lys 242 | - | expression tag |
Lys 243 | - | expression tag |
Leu 244 | - | expression tag |
Val 245 | - | expression tag |
Gly 246 | - | expression tag |
Glu 247 | - | expression tag |
Arg 248 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 4 |
Total formula weight | 291844.4 | |
Non-Polymers* | Number of molecules | 4 |
Total formula weight | 1388.9 | |
All* | Total formula weight | 293233.3 |