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8EWY

Structure of Janus Kinase (JAK) dimer complexed with cytokine receptor intracellular domain

Functional Information from GO Data
ChainGOidnamespacecontents
A0000166molecular_functionnucleotide binding
A0004672molecular_functionprotein kinase activity
A0004713molecular_functionprotein tyrosine kinase activity
A0004715molecular_functionnon-membrane spanning protein tyrosine kinase activity
A0005131molecular_functiongrowth hormone receptor binding
A0005524molecular_functionATP binding
A0005634cellular_componentnucleus
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0006468biological_processprotein phosphorylation
A0007259biological_processcell surface receptor signaling pathway via JAK-STAT
A0009898cellular_componentcytoplasmic side of plasma membrane
A0012505cellular_componentendomembrane system
A0016020cellular_componentmembrane
A0016301molecular_functionkinase activity
A0016740molecular_functiontransferase activity
A0019221biological_processcytokine-mediated signaling pathway
A0019903molecular_functionprotein phosphatase binding
A0031234cellular_componentextrinsic component of cytoplasmic side of plasma membrane
A0031625molecular_functionubiquitin protein ligase binding
A0031730molecular_functionCCR5 chemokine receptor binding
A0034112biological_processpositive regulation of homotypic cell-cell adhesion
A0035556biological_processintracellular signal transduction
A0035723biological_processinterleukin-15-mediated signaling pathway
A0035771biological_processinterleukin-4-mediated signaling pathway
A0035772biological_processinterleukin-13-mediated signaling pathway
A0038110biological_processinterleukin-2-mediated signaling pathway
A0038113biological_processinterleukin-9-mediated signaling pathway
A0038154biological_processinterleukin-11-mediated signaling pathway
A0038165biological_processoncostatin-M-mediated signaling pathway
A0048861biological_processleukemia inhibitory factor signaling pathway
A0060333biological_processtype II interferon-mediated signaling pathway
A0060337biological_processtype I interferon-mediated signaling pathway
A0060397biological_processgrowth hormone receptor signaling pathway via JAK-STAT
A0070102biological_processinterleukin-6-mediated signaling pathway
A0070120biological_processciliary neurotrophic factor-mediated signaling pathway
A0098761biological_processcellular response to interleukin-7
A0140105biological_processinterleukin-10-mediated signaling pathway
A0140854biological_processinterleukin-19-mediated signaling pathway
A0150105biological_processprotein localization to cell-cell junction
A1900182biological_processpositive regulation of protein localization to nucleus
A1903672biological_processpositive regulation of sprouting angiogenesis
B0000166molecular_functionnucleotide binding
B0004672molecular_functionprotein kinase activity
B0004713molecular_functionprotein tyrosine kinase activity
B0004715molecular_functionnon-membrane spanning protein tyrosine kinase activity
B0005131molecular_functiongrowth hormone receptor binding
B0005524molecular_functionATP binding
B0005634cellular_componentnucleus
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0006468biological_processprotein phosphorylation
B0007259biological_processcell surface receptor signaling pathway via JAK-STAT
B0009898cellular_componentcytoplasmic side of plasma membrane
B0012505cellular_componentendomembrane system
B0016020cellular_componentmembrane
B0016301molecular_functionkinase activity
B0016740molecular_functiontransferase activity
B0019221biological_processcytokine-mediated signaling pathway
B0019903molecular_functionprotein phosphatase binding
B0031234cellular_componentextrinsic component of cytoplasmic side of plasma membrane
B0031625molecular_functionubiquitin protein ligase binding
B0031730molecular_functionCCR5 chemokine receptor binding
B0034112biological_processpositive regulation of homotypic cell-cell adhesion
B0035556biological_processintracellular signal transduction
B0035723biological_processinterleukin-15-mediated signaling pathway
B0035771biological_processinterleukin-4-mediated signaling pathway
B0035772biological_processinterleukin-13-mediated signaling pathway
B0038110biological_processinterleukin-2-mediated signaling pathway
B0038113biological_processinterleukin-9-mediated signaling pathway
B0038154biological_processinterleukin-11-mediated signaling pathway
B0038165biological_processoncostatin-M-mediated signaling pathway
B0048861biological_processleukemia inhibitory factor signaling pathway
B0060333biological_processtype II interferon-mediated signaling pathway
B0060337biological_processtype I interferon-mediated signaling pathway
B0060397biological_processgrowth hormone receptor signaling pathway via JAK-STAT
B0070102biological_processinterleukin-6-mediated signaling pathway
B0070120biological_processciliary neurotrophic factor-mediated signaling pathway
B0098761biological_processcellular response to interleukin-7
B0140105biological_processinterleukin-10-mediated signaling pathway
B0140854biological_processinterleukin-19-mediated signaling pathway
B0150105biological_processprotein localization to cell-cell junction
B1900182biological_processpositive regulation of protein localization to nucleus
B1903672biological_processpositive regulation of sprouting angiogenesis
C0003700molecular_functionDNA-binding transcription factor activity
C0006355biological_processregulation of DNA-templated transcription
D0003700molecular_functionDNA-binding transcription factor activity
D0006355biological_processregulation of DNA-templated transcription
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues556
DetailsDomain: {"description":"Protein kinase 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI2
Number of Residues2
DetailsActive site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"},{"source":"PROSITE-ProRule","id":"PRU10028","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI3
Number of Residues18
DetailsBinding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI4
Number of Residues2
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P23458","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI5
Number of Residues4
DetailsModified residue: {"description":"Phosphotyrosine; by autocatalysis","evidences":[{"source":"UniProtKB","id":"P23458","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

256158

PDB entries from 2026-07-08

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