8EVC
Cryo-EM structure of cGMP bound truncated human CNGA3/CNGB3 channel in lipid nanodisc, open state
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C (A, B, C) | Cyclic nucleotide-gated cation channel alpha-3 | polymer | 552 | 63402.8 | 3 | UniProt (Q16281) Pfam (PF00520) Pfam (PF00027) Pfam (PF16526) | Homo sapiens (human) | Cone photoreceptor cGMP-gated channel subunit alpha,Cyclic nucleotide-gated channel alpha-3,CNG channel alpha-3,CNG-3,CNG3 |
| 2 | D (D) | Cyclic nucleotide-gated cation channel beta-3 | polymer | 740 | 84637.2 | 1 | UniProt (Q9NQW8) Pfam (PF00520) Pfam (PF00027) | Homo sapiens (human) | Cone photoreceptor cGMP-gated channel subunit beta,Cyclic nucleotide-gated cation channel modulatory subunit,Cyclic nucleotide-gated channel beta-3,CNG channel beta-3 |
| 3 | E, G, I (A, B, C) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 3 | Chemie (NAG) | |||
| 4 | F, H, J, K (A, B, C, D) | CYCLIC GUANOSINE MONOPHOSPHATE | non-polymer | 345.2 | 4 | Chemie (PCG) PubChem (177270406) PubChem (136759845) PubChem (135398570) PubChem (135402012) PubChem (135415582) PubChem (135530416) PubChem (135566687) PubChem (135612771) PubChem (136122637) PubChem (136183234) PubChem (136183235) PubChem (136239427) PubChem (136268916) PubChem (136454903) PubChem (136454906) PubChem (136488083) PubChem (136488088) PubChem (136499047) PubChem (136678837) PubChem (137218937) PubChem (137234705) PubChem (137279777) PubChem (138399475) PubChem (164162904) |
Sequence modifications
A, B, C: 151 - 694 (UniProt: Q16281)
D: 79 - 809 (UniProt: Q9NQW8)
| PDB | External Database | Details |
|---|---|---|
| Met 143 | - | initiating methionine |
| Asp 144 | - | expression tag |
| Tyr 145 | - | expression tag |
| Lys 146 | - | expression tag |
| Asp 147 | - | expression tag |
| Asp 148 | - | expression tag |
| Asp 149 | - | expression tag |
| Asp 150 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Met 70 | - | initiating methionine |
| Asp 71 | - | expression tag |
| Tyr 72 | - | expression tag |
| Lys 73 | - | expression tag |
| Asp 74 | - | expression tag |
| Asp 75 | - | expression tag |
| Asp 76 | - | expression tag |
| Asp 77 | - | expression tag |
| Lys 78 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 274845.7 | |
| Non-Polymers* | Number of molecules | 7 |
| Total formula weight | 2044.4 | |
| All* | Total formula weight | 276890.1 |
