8EV9
Cryo-EM structure of cGMP bound truncated human CNGA3/CNGB3 channel in lipid nanodisc, transition state 1
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B, C | Cyclic nucleotide-gated cation channel alpha-3 | polymer | 552 | 63402.8 | 3 | UniProt (Q16281) Pfam (PF00520) Pfam (PF00027) Pfam (PF16526) In PDB | Homo sapiens (human) | Cone photoreceptor cGMP-gated channel subunit alpha,Cyclic nucleotide-gated channel alpha-3,CNG channel alpha-3,CNG-3,CNG3 |
2 | D | Cyclic nucleotide-gated cation channel beta-3 | polymer | 740 | 84637.2 | 1 | UniProt (Q9NQW8) Pfam (PF00520) Pfam (PF00027) In PDB | Homo sapiens (human) | Cone photoreceptor cGMP-gated channel subunit beta,Cyclic nucleotide-gated cation channel modulatory subunit,Cyclic nucleotide-gated channel beta-3,CNG channel beta-3 |
3 | A, B, C | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 3 | Chemie (NAG) | |||
4 | A, B, C, D | CYCLIC GUANOSINE MONOPHOSPHATE | non-polymer | 345.2 | 4 | Chemie (PCG) |
Sequence modifications
A, B, C: 151 - 694 (UniProt: Q16281)
D: 79 - 809 (UniProt: Q9NQW8)
PDB | External Database | Details |
---|---|---|
Met 143 | - | initiating methionine |
Asp 144 | - | expression tag |
Tyr 145 | - | expression tag |
Lys 146 | - | expression tag |
Asp 147 | - | expression tag |
Asp 148 | - | expression tag |
Asp 149 | - | expression tag |
Asp 150 | - | expression tag |
PDB | External Database | Details |
---|---|---|
Met 70 | - | initiating methionine |
Asp 71 | - | expression tag |
Tyr 72 | - | expression tag |
Lys 73 | - | expression tag |
Asp 74 | - | expression tag |
Asp 75 | - | expression tag |
Asp 76 | - | expression tag |
Asp 77 | - | expression tag |
Lys 78 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 4 |
Total formula weight | 274845.7 | |
Non-Polymers* | Number of molecules | 7 |
Total formula weight | 2044.4 | |
All* | Total formula weight | 276890.1 |