8EV1
Dual Modulators
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Estrogen Receptor | polymer | 257 | 29356.6 | 1 | UniProt (P03372) Pfam (PF00104) | Homo sapiens (human) | |
| 2 | B (B) | Estrogen receptor | polymer | 257 | 29413.6 | 1 | UniProt (P03372) Pfam (PF00104) | Homo sapiens (human) | ER,ER-alpha,Estradiol receptor,Nuclear receptor subfamily 3 group A member 1 |
| 3 | C, D (C, D) | Nuclear receptor coactivator 2 | polymer | 13 | 1579.9 | 2 | UniProt (Q15596) | Homo sapiens | NCoA-2,Class E basic helix-loop-helix protein 75,bHLHe75,Transcriptional intermediary factor 2,hTIF2 |
| 4 | E, G (A, B) | (3aS,4R,9bR)-4-(4-hydroxyphenyl)-2,3,3a,4,5,9b-hexahydro-1H-cyclopenta[c]quinoline-8-sulfonamide | non-polymer | 344.4 | 2 | Chemie (WVW) | |||
| 5 | F (A) | (3aR,4S,9bS)-4-(4-hydroxyphenyl)-2,3,3a,4,5,9b-hexahydro-1H-cyclopenta[c]quinoline-8-sulfonamide | non-polymer | 344.4 | 1 | Chemie (WVR) | |||
| 6 | H, I, J (A, B, C) | water | water | 18.0 | 129 | Chemie (HOH) |
Sequence modifications
A: 298 - 554 (UniProt: P03372)
B: 298 - 554 (UniProt: P03372)
| PDB | External Database | Details |
|---|---|---|
| Ser 537 | Tyr 537 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Ser 537 | Tyr 537 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 61930.0 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 1033.3 | |
| All* | Total formula weight | 62963.2 |
