8EUS

Crystal structure of NPC1 luminal domain C

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (C, A)	NPC intracellular cholesterol transporter 1	polymer	262	30167.5	2	UniProt (O15118) Pfam (PF22314)	Homo sapiens (human)	Niemann-Pick C1 protein
2	C, D (C, A)	water	water		18.0	160	Chemie (HOH)

Sequence modifications

C, A: 371 - 621 (UniProt: O15118)

PDB	External Database	Details
Met 370	-	initiating methionine
Leu 622	-	expression tag
Glu 623	-	expression tag
His 624	-	expression tag
His 625	-	expression tag
His 626	-	expression tag
His 627	-	expression tag
His 628	-	expression tag
His 629	-	expression tag
His 630	-	expression tag
His 631	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	60334.9
All*	Total formula weight	60334.9

*Water molecules are not included.