8ES7
CryoEM structure of PN45545 TCR-CD3 complex
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | Z, Y | T-cell surface glycoprotein CD3 zeta chain | polymer | 173 | 19654.5 | 2 | UniProt (P20963) Pfam (PF11628) Pfam (PF02189) In PDB | Homo sapiens (human) | T-cell receptor T3 zeta chain |
| 2 | D | T-cell surface glycoprotein CD3 delta chain | polymer | 174 | 19150.7 | 1 | UniProt (P04234) Pfam (PF16680) Pfam (PF02189) In PDB | Homo sapiens (human) | T-cell receptor T3 delta chain |
| 3 | F, E | T-cell surface glycoprotein CD3 epsilon chain | polymer | 211 | 23432.5 | 2 | UniProt (P07766) Pfam (PF16681) Pfam (PF02189) In PDB | Homo sapiens (human) | T-cell surface antigen T3/Leu-4 epsilon chain |
| 4 | G | T-cell surface glycoprotein CD3 gamma chain | polymer | 185 | 20694.6 | 1 | UniProt (P09693) Pfam (PF16680) Pfam (PF02189) In PDB | Homo sapiens (human) | T-cell receptor T3 gamma chain |
| 5 | A | PN45545 TCR alpha chain | polymer | 278 | 30737.5 | 1 | Homo sapiens (human) | ||
| 6 | B | PN45545 TCR beta chain | polymer | 319 | 35891.9 | 1 | Homo sapiens (Human) | ||
| 7 | C | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 586.5 | 1 | In PDB GlyTouCan (G15407YE) | |||
| 8 | O, P, N, H, J | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 5 | In PDB GlyTouCan (G42666HT) | |||
| 9 | Y | CHOLESTEROL HEMISUCCINATE | non-polymer | 486.7 | 1 | Chemie (Y01) | |||
| 10 | G, A, B | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 5 | Chemie (NAG) |
Sequence modifications
Z, Y: 1 - 164 (UniProt: P20963)
D: 1 - 171 (UniProt: P04234)
F, E: 2 - 207 (UniProt: P07766)
G: 1 - 182 (UniProt: P09693)
| PDB | External Database | Details |
|---|---|---|
| Gly 165 | - | expression tag |
| Ser 166 | - | expression tag |
| Gly 167 | - | expression tag |
| Leu 168 | - | expression tag |
| Glu 169 | - | expression tag |
| Val 170 | - | expression tag |
| Leu 171 | - | expression tag |
| Phe 172 | - | expression tag |
| Gln 173 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Gly 172 | - | expression tag |
| Ser 173 | - | expression tag |
| Gly 174 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Met 0 | - | expression tag |
| Gly 1 | - | expression tag |
| Gly 208 | - | expression tag |
| Ser 209 | - | expression tag |
| Gly 210 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Gly 183 | - | expression tag |
| Ser 184 | - | expression tag |
| Gly 185 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 8 |
| Total formula weight | 192648.6 | |
| Branched | Number of molecules | 6 |
| Total formula weight | 2708.5 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 1592.8 | |
| All* | Total formula weight | 196949.9 |
