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8EQE

Co-crystal structure of PERK with compound 26

This is a non-PDB format compatible entry.
Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1AAAEukaryotic translation initiation factor 2-alpha kinase 3polymer31736816.41UniProt (Q9NZJ5)
Pfam (PF00069)
In PDB
Homo sapiens (human)PRKR-like endoplasmic reticulum kinase,Pancreatic eIF2-alpha kinase,HsPEK
2AAA(2R)-N-[(4M)-4-(4-amino-2,7-dimethyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-3-methylphenyl]-2-hydroxy-2-[3-(trifluoromethyl)phenyl]acetamidenon-polymer469.51Chemie (WQ2)
3waterwater18.06Chemie (HOH)
Sequence modifications
AAA: 575 - 872 (UniProt: Q9NZJ5)
PDBExternal DatabaseDetails
Gly 573-expression tag
Ser 574-expression tag
AAA: 873 - 1094 (UniProt: Q9NZJ5)
PDBExternal DatabaseDetails
Asn 937Asp 937engineered mutation
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains1
Total formula weight36816.4
Non-Polymers*Number of molecules1
Total formula weight469.5
All*Total formula weight37285.8
*Water molecules are not included.

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PDB entries from 2024-06-12

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