8EQ5
Crystal structure of the N-terminal kinase domain of RSK2 in complex with SPRED2 (131-160)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Ribosomal protein S6 kinase alpha-3 | polymer | 305 | 35070.8 | 1 | UniProt (P51812) Pfam (PF00069) | Homo sapiens (human) | S6K-alpha-3,90 kDa ribosomal protein S6 kinase 3,p90-RSK 3,p90RSK3,Insulin-stimulated protein kinase 1,ISPK-1,MAP kinase-activated protein kinase 1b,MAPK-activated protein kinase 1b,MAPKAP kinase 1b,MAPKAPK-1b,Ribosomal S6 kinase 2,RSK-2,pp90RSK2 |
| 2 | B (B) | Sprouty-related, EVH1 domain-containing protein 2 | polymer | 30 | 3245.3 | 1 | UniProt (Q7Z698) | Homo sapiens | Spred-2 |
| 3 | C (A) | 2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4-oxo-4H-chromen-3-yl 6-deoxy-alpha-L-mannopyranoside | non-polymer | 448.4 | 1 | Chemie (QCT) PubChem (5320477) PubChem (5320854) PubChem (5353915) PubChem (5702146) PubChem (6325794) PubChem (6710619) PubChem (11972444) PubChem (12314853) PubChem (12314855) PubChem (12314856) PubChem (12314859) PubChem (16667665) PubChem (16758176) PubChem (18604930) PubChem (21550894) PubChem (23304560) PubChem (24211982) PubChem (25141341) PubChem (26339717) PubChem (40469466) PubChem (40486293) PubChem (44259217) PubChem (49847482) PubChem (54174440) PubChem (69916642) PubChem (51402819) PubChem (51402820) PubChem (51403177) PubChem (51403178) PubChem (5280459) PubChem (5320852) PubChem (5359430) PubChem (124425448) PubChem (124540693) PubChem (10072329) PubChem (15939939) PubChem (162903258) PubChem (89864329) PubChem (90882953) PubChem (144163037) PubChem (162903256) PubChem (162903257) PubChem (162903259) | |||
| 4 | D, E (A, B) | water | water | 18.0 | 139 | Chemie (HOH) |
Sequence modifications
A: 46 - 346 (UniProt: P51812)
| PDB | External Database | Details |
|---|---|---|
| Gly 42 | - | expression tag |
| Ala 43 | - | expression tag |
| Met 44 | - | expression tag |
| Gly 45 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 38316.1 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 448.4 | |
| All* | Total formula weight | 38764.5 |
