8EOP
Cryo-EM Structure of Nanodisc reconstituted human ABCA7 EQ mutant in ATP bound closed state
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Phospholipid-transporting ATPase ABCA7 | polymer | 2146 | 234596.6 | 1 | UniProt (Q8IZY2) Pfam (PF12698) Pfam (PF00005) Pfam (PF23321) | Homo sapiens (human) | ABCA-SSN,ATP-binding cassette sub-family A member 7,Autoantigen SS-N,Macrophage ABC transporter |
| 2 | B (C) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 1 | In PDB GlyTouCan (G42666HT) | |||
| 3 | C (B) | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 586.5 | 1 | In PDB GlyTouCan (G15407YE) | |||
| 4 | D, E, F, G, H... (A) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 6 | Chemie (NAG) | |||
| 5 | J, M (A) | ADENOSINE-5'-TRIPHOSPHATE | non-polymer | 507.2 | 2 | Chemie (ATP) | |||
| 6 | K, L (A) | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) |
Sequence modifications
A: 1 - 2146 (UniProt: Q8IZY2)
| PDB | External Database | Details |
|---|---|---|
| Gln 965 | Glu 965 | engineered mutation |
| Gln 1951 | Glu 1951 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 234596.6 | |
| Branched | Number of molecules | 2 |
| Total formula weight | 1010.9 | |
| Non-Polymers* | Number of molecules | 10 |
| Total formula weight | 2390.2 | |
| All* | Total formula weight | 237997.8 |
