8ENU

Structure of the C3bB proconvertase in complex with lufaxin

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (G)	Complement C3 beta chain	polymer	645	71393.3	1	UniProt (P01024) Pfam (PF07703) Pfam (PF17790) Pfam (PF01835) Pfam (PF17791) Pfam (PF17789)	Homo sapiens (human)
2	B (H)	Complement C3b alpha' chain	polymer	915	104074.1	1	UniProt (P01024) Pfam (PF00207) Pfam (PF21406) Pfam (PF07678) Pfam (PF21308) Pfam (PF07677) Pfam (PF01759)	Homo sapiens (human)
3	C (D)	Complement factor B	polymer	763	85510.6	1	UniProt (P00751) Pfam (PF00084) Pfam (PF00092) Pfam (PF00089)	Homo sapiens (human)	C3/C5 convertase,Glycine-rich beta glycoprotein,GBG,PBF2,Properdin factor B
4	D (A)	Lufaxin	polymer	278	32525.7	1	UniProt (Q5WPU8)	Lutzomyia longipalpis	32.4 kDa salivary protein,Lutzomyia longipalpis FXa inhibitor
5	E, F (B, C)	beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		586.5	2	In PDB GlyTouCan (G15407YE)
6	G (E)	beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-6)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		586.5	1	In PDB GlyTouCan (G62916OK)
7	H, I, J, K (H, D)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	4	Chemie (NAG)

Sequence modifications

H: 727 - 1641 (UniProt: P01024)

PDB	External Database	Details
Glu 991	Gln 1013	conflict

A: 1 - 278 (UniProt: Q5WPU8)

PDB	External Database	Details
Arg 75	Lys 98	conflict
Ser 134	Pro 157	conflict
Leu 145	Val 168	conflict
Asn 148	Tyr 171	conflict

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	293503.8
Branched	Number of molecules	3
	Total formula weight	1759.6
Non-Polymers*	Number of molecules	4
	Total formula weight	884.8
All*	Total formula weight	296148.3

*Water molecules are not included.