8ENU
Structure of the C3bB proconvertase in complex with lufaxin
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | G | Complement C3 beta chain | polymer | 645 | 71393.3 | 1 | UniProt (P01024) Pfam (PF07703) Pfam (PF17790) Pfam (PF01835) Pfam (PF17791) Pfam (PF17789) In PDB | Homo sapiens (human) | |
2 | H | Complement C3b alpha' chain | polymer | 915 | 104074.1 | 1 | UniProt (P01024) Pfam (PF00207) Pfam (PF21406) Pfam (PF07678) Pfam (PF21308) Pfam (PF07677) Pfam (PF01759) In PDB | Homo sapiens (human) | |
3 | D | Complement factor B | polymer | 763 | 85510.6 | 1 | UniProt (P00751) Pfam (PF00084) Pfam (PF00092) Pfam (PF00089) In PDB | Homo sapiens (human) | C3/C5 convertase,Glycine-rich beta glycoprotein,GBG,PBF2,Properdin factor B |
4 | A | Lufaxin | polymer | 278 | 32525.7 | 1 | UniProt (Q5WPU8) In PDB | Lutzomyia longipalpis | 32.4 kDa salivary protein,Lutzomyia longipalpis FXa inhibitor |
5 | B, C | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 586.5 | 2 | In PDB GlyTouCan (G15407YE) | |||
6 | E | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-6)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 586.5 | 1 | In PDB GlyTouCan (G62916OK) | |||
7 | H, D | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 4 | Chemie (NAG) |
Sequence modifications
H: 727 - 1641 (UniProt: P01024)
A: 1 - 278 (UniProt: Q5WPU8)
PDB | External Database | Details |
---|---|---|
Glu 991 | Gln 1013 | conflict |
PDB | External Database | Details |
---|---|---|
Arg 75 | Lys 98 | conflict |
Ser 134 | Pro 157 | conflict |
Leu 145 | Val 168 | conflict |
Asn 148 | Tyr 171 | conflict |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 4 |
Total formula weight | 293503.8 | |
Branched | Number of molecules | 3 |
Total formula weight | 1759.6 | |
Non-Polymers* | Number of molecules | 4 |
Total formula weight | 884.8 | |
All* | Total formula weight | 296148.3 |