8ENU
Structure of the C3bB proconvertase in complex with lufaxin
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005576 | cellular_component | extracellular region |
| A | 0035821 | biological_process | modulation of process of another organism |
| A | 0090729 | molecular_function | toxin activity |
| D | 0004252 | molecular_function | serine-type endopeptidase activity |
| D | 0005576 | cellular_component | extracellular region |
| D | 0006508 | biological_process | proteolysis |
| D | 0006956 | biological_process | complement activation |
| G | 0004866 | molecular_function | endopeptidase inhibitor activity |
| H | 0004866 | molecular_function | endopeptidase inhibitor activity |
| H | 0005576 | cellular_component | extracellular region |
| H | 0005615 | cellular_component | extracellular space |
Functional Information from PROSITE/UniProt
| site_id | PS00134 |
| Number of Residues | 6 |
| Details | TRYPSIN_HIS Serine proteases, trypsin family, histidine active site. LTAAHC |
| Chain | Residue | Details |
| D | LEU497-CYS502 |
| site_id | PS00135 |
| Number of Residues | 12 |
| Details | TRYPSIN_SER Serine proteases, trypsin family, serine active site. NTcrGDSGGPLI |
| Chain | Residue | Details |
| D | ASN668-ILE679 |
| site_id | PS00477 |
| Number of Residues | 9 |
| Details | ALPHA_2_MACROGLOBULIN Alpha-2-macroglobulin family thiolester region signature. PsGCGEEnM |
| Chain | Residue | Details |
| H | PRO985-MET993 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255|PROSITE-ProRule:PRU00498, ECO:0000305|PubMed:22796577 |
| Chain | Residue | Details |
| A | ASN239 | |
| D | ASP551 | |
| D | SER674 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:16335952, ECO:0000269|PubMed:17310251, ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:6546754 |
| Chain | Residue | Details |
| D | ASN97 | |
| D | ASN260 | |
| G | SER275 | |
| G | SER281 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:17310251, ECO:0000269|PubMed:19574954, ECO:0000269|PubMed:6546754 |
| Chain | Residue | Details |
| D | ASN117 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | CARBOHYD: N-linked (Glc) (glycation) lysine => ECO:0000269|PubMed:2006911 |
| Chain | Residue | Details |
| D | LYS266 | |
| H | SER1299 | |
| H | SER1551 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:16335952, ECO:0000269|PubMed:17310251, ECO:0000269|PubMed:19574954, ECO:0000269|PubMed:6546754 |
| Chain | Residue | Details |
| D | ASN353 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:16335952 |
| Chain | Residue | Details |
| H | ASN1595 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | CROSSLNK: Isoglutamyl cysteine thioester (Cys-Gln) |
| Chain | Residue | Details |
| H | CYS988 | |
| H | GLU991 |
