8ENC
Helical reconstruction of the human cardiac actin-tropomyosin-myosin loop 4 7G mutant complex
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | M | Myosin-7 | polymer | 1935 | 222931.3 | 1 | UniProt (P12883) Pfam (PF02736) Pfam (PF00063) Pfam (PF01576) In PDB | Homo sapiens (human) | Myosin heavy chain 7,Myosin heavy chain slow isoform,MyHC-slow,Myosin heavy chain,cardiac muscle beta isoform,MyHC-beta |
| 2 | B, C, D, E, F | Actin, alpha cardiac muscle 1 | polymer | 377 | 42064.9 | 5 | UniProt (B6VNT8) Pfam (PF00022) In PDB | Sus scrofa (pig) | Cardiac muscle alpha actin 1 |
| 3 | O, P | Tropomyosin alpha-1 chain | polymer | 284 | 32763.6 | 2 | UniProt (P09493) Pfam (PF00261) In PDB | Homo sapiens (human) | Alpha-tropomyosin,Tropomyosin-1 |
| 4 | B, C, D, E, F | ADENOSINE-5'-DIPHOSPHATE | non-polymer | 427.2 | 5 | Chemie (ADP) | |||
| 5 | B, C, D, E, F | MAGNESIUM ION | non-polymer | 24.3 | 5 | Chemie (MG) |
Sequence modifications
M: 1 - 1935 (UniProt: P12883)
| PDB | External Database | Details |
|---|---|---|
| Gly 366 | Leu 366 | engineered mutation |
| Gly 367 | Lys 367 | engineered mutation |
| Gly 368 | Gln 368 | engineered mutation |
| Gly 369 | Arg 369 | engineered mutation |
| Gly 370 | Glu 370 | engineered mutation |
| Gly 371 | Glu 371 | engineered mutation |
| Gly 372 | Gln 372 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 8 |
| Total formula weight | 498783.0 | |
| Non-Polymers* | Number of molecules | 10 |
| Total formula weight | 2257.5 | |
| All* | Total formula weight | 501040.6 |
