8EKA
Cryo-EM structure of a potent anti-malarial antibody L9 in complex with Plasmodium falciparum circumsporozoite protein (PfCSP)(class 2)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (P) | Circumsporozoite protein | polymer | 355 | 37807.5 | 1 | UniProt (Q7K740) Pfam (PF00090) | Plasmodium falciparum 3D7 | CS,PfCSP |
| 2 | B, D, F (H, A, C) | L9 Fab heavy chain | polymer | 227 | 24475.4 | 3 | Homo sapiens | ||
| 3 | C, E, G (L, B, D) | L9 Fab light chain | polymer | 214 | 23597.3 | 3 | Homo sapiens (human) |
Sequence modifications
P: -83 - 271 (UniProt: Q7K740)
| PDB | External Database | Details |
|---|---|---|
| Ser -79 | Cys 25 | engineered mutation |
| Ser -38 | Lys 66 | engineered mutation |
| Ser -37 | Lys 67 | engineered mutation |
| Ala -34 | Arg 70 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 7 |
| Total formula weight | 182025.6 | |
| All* | Total formula weight | 182025.6 |
