8EI7
Crystal structure of the WWP2 HECT domain in complex with H304, a Helicon Polypeptide
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | NEDD4-like E3 ubiquitin-protein ligase WWP2 | polymer | 376 | 44925.4 | 2 | UniProt (O00308) Pfam (PF00632) | Homo sapiens (human) | Atrophin-1-interacting protein 2,AIP2,HECT-type E3 ubiquitin transferase WWP2,WW domain-containing protein 2 |
| 2 | C (C) | H304 | polymer | 19 | 2109.5 | 1 | synthetic construct | ||
| 3 | D, E (A) | GLYCEROL | non-polymer | 92.1 | 2 | Chemie (GOL) | |||
| 4 | F, G, H, I, J... (A, B) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 10 | Chemie (EDO) | |||
| 5 | L, S (A, B) | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
| 6 | M (B) | TRIETHYLENE GLYCOL | non-polymer | 150.2 | 1 | Chemie (PGE) | |||
| 7 | N (B) | DI(HYDROXYETHYL)ETHER | non-polymer | 106.1 | 1 | Chemie (PEG) | |||
| 8 | T (C) | N,N'-(1,4-phenylene)diacetamide | non-polymer | 192.2 | 1 | Chemie (WHL) | |||
| 9 | U, V, W (A, B, C) | water | water | 18.0 | 194 | Chemie (HOH) |
Sequence modifications
A, B: 492 - 865 (UniProt: O00308)
| PDB | External Database | Details |
|---|---|---|
| Gly 490 | - | expression tag |
| Pro 491 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 91960.2 | |
| Non-Polymers* | Number of molecules | 17 |
| Total formula weight | 1384.2 | |
| All* | Total formula weight | 93344.4 |
