8EHV
Kelch domain of human KEAP1 bound to Nrf2 cyclic peptide, c[DhA-GDPET(bAla)E]
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | Kelch-like ECH-associated protein 1 | polymer | 336 | 36899.2 | 2 | UniProt (Q14145) Pfam (PF01344) In PDB | Homo sapiens (human) | Cytosolic inhibitor of Nrf2,INrf2,Kelch-like protein 19 |
2 | P | cyclic peptide c[DhA-GDPET(bAla)E | polymer | 7 | 745.7 | 1 | synthetic construct | ||
3 | water | water | 18.0 | 190 | Chemie (HOH) |
Sequence modifications
A, B: 312 - 624 (UniProt: Q14145)
PDB | External Database | Details |
---|---|---|
Met 289 | - | expression tag |
Gly 290 | - | expression tag |
Ser 291 | - | expression tag |
Ser 292 | - | expression tag |
His 293 | - | expression tag |
His 294 | - | expression tag |
His 295 | - | expression tag |
His 296 | - | expression tag |
His 297 | - | expression tag |
His 298 | - | expression tag |
Ser 299 | - | expression tag |
Ser 300 | - | expression tag |
Gly 301 | - | expression tag |
Gly 302 | - | expression tag |
Glu 303 | - | expression tag |
Asn 304 | - | expression tag |
Leu 305 | - | expression tag |
Tyr 306 | - | expression tag |
Phe 307 | - | expression tag |
Gln 308 | - | expression tag |
Gly 309 | - | expression tag |
His 310 | - | expression tag |
Met 311 | - | expression tag |
Ser 319 | Cys 319 | conflict |
Ala 540 | Glu 540 | engineered mutation |
Ala 542 | Glu 542 | engineered mutation |
Ser 613 | Cys 613 | engineered mutation |
Ser 622 | Cys 622 | conflict |
Ser 624 | Cys 624 | conflict |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 3 |
Total formula weight | 74544.1 | |
All* | Total formula weight | 74544.1 |