8EFL
SR17018-bound mu-opioid receptor-Gi complex
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | R, M | Mu-type opioid receptor | polymer | 367 | 41072.2 | 2 | UniProt (P35372) Pfam (PF00001) In PDB | Homo sapiens (human) | M-OR-1,MOR-1,Mu opiate receptor,Mu opioid receptor,MOP,hMOP |
2 | A, F | Guanine nucleotide-binding protein G(i) subunit alpha-1 | polymer | 354 | 40445.1 | 2 | UniProt (P63096) Pfam (PF00503) In PDB | Homo sapiens (human) | Adenylate cyclase-inhibiting G alpha protein |
3 | B | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | polymer | 353 | 39020.7 | 1 | UniProt (P54311) Pfam (PF00400) In PDB | Rattus norvegicus (Rat) | Transducin beta chain 1 |
4 | C | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 | polymer | 68 | 7563.8 | 1 | UniProt (P59768) Pfam (PF00631) In PDB | Homo sapiens (human) | G gamma-I |
5 | E | scFv16 | polymer | 248 | 26408.5 | 1 | Homo sapiens | ||
6 | R, M | 5,6-dichloro-1-{1-[(4-chlorophenyl)methyl]piperidin-4-yl}-1,3-dihydro-2H-benzimidazol-2-one | non-polymer | 410.7 | 2 | Chemie (WH9) | |||
7 | R, M | CHOLESTEROL | non-polymer | 386.7 | 10 | Chemie (CLR) |
Sequence modifications
A, F: 1 - 354 (UniProt: P63096)
B: 2 - 340 (UniProt: P54311)
PDB | External Database | Details |
---|---|---|
Ala 203 | Gly 203 | conflict |
Ser 326 | Ala 326 | conflict |
PDB | External Database | Details |
---|---|---|
Met -12 | - | expression tag |
His -11 | - | expression tag |
His -10 | - | expression tag |
His -9 | - | expression tag |
His -8 | - | expression tag |
His -7 | - | expression tag |
His -6 | - | expression tag |
His -5 | - | expression tag |
His -4 | - | expression tag |
Gly -3 | - | expression tag |
Ser -2 | - | expression tag |
Leu -1 | - | expression tag |
Leu 0 | - | expression tag |
Gln 1 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 7 |
Total formula weight | 236027.4 | |
Non-Polymers* | Number of molecules | 12 |
Total formula weight | 4688.0 | |
All* | Total formula weight | 240715.4 |